Study of nasopharyngeal bacterial flora. Second report. Variations in nasopharyngeal bacterial flora in children aged 6 years or younger when administered antimicrobial agents. Part 2.

Abstract

This report focuses on changes in the nasopharyngeal bacterial flora before and after administration of antimicrobial agents in 172 cases of acute upper respiratory infection in patients aged 6 years or younger. The antimicrobial agents administered were amoxicillin (AMPC) (34%), clavulanic acid/amoxicillin compound (11%), cefditren pivoxil (CDTR-PI) (43%), and others (12%). Changes in nasopharyngeal bacterial flora were investigated with reexaminations conducted after 2-5 days (day 2-5 subgroup), 6-10 days (day 6-10 subgroup), and 11 days and thereafter. There was a significant reduction in the Streptococcus pneumoniae detected in the group administered AMPC (AMPC group) in the day 2-5 subgroup and the day 6-10 subgroup. There was also a significant decrease in H. influenzae in the group administered CDTR-PI (CDTR-PI group) in the day 2-5 subgroup. From this it was inferred that for the most part significant changes in infectious nasopharyngeal bacteria occurred in the day 2-5 subgroups. However, a significant improvement in the degree of inflammation, as indicated by leukocyte infiltration images for the AMPC group, was observed in the day 2-5 subgroup, and for the CDTR-PI group in the day 6-10 subgroup. On the other hand, in both the antimicrobial agent groups, S. pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis were newly detected at reexamination. Furthermore, a difference in the incidence of these bacteria was observed between the 2 antimicrobial agent groups. It was suggested that such phenomena related to the survival of resistant strains or a recurrence otitis media.

• Authors: Masatoshi Konno, Shunkichi Baba, Haruki Mikawa, Kohei Hara, Fumio Matsumoto, Kimitaka Kaga, Tadao Nishimura, Toshimitsu Kobayashi, Nobuhiko Furuya, Hiroshi Moriyama, Yoshitaka Okamoto, Mituru Furukawa, Noboru Yamanaka, Toshiharu Matsushima, Yasuyuki Yoshizawa, Shigeru Kohno, Kunihiko Kobayashi, Akihiro Morikawa, Shoichi Koizumi, Keisuke Sunakawa, Matsuhisa Inoue, Kimiko Ubukata
• Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy (J Infect Chemother) Vol. 12 Issue 5 Pg. 305-30 (Oct 2006) ISSN: 1341-321X [Print] Netherlands
• PMID: 17109095 (Publication Type: Journal Article)

Chemical References

• Anti-Infective Agents

Topics

• Anti-Infective Agents (therapeutic use)
• Child
• Child, Preschool
• Drug Resistance
• Female
• Haemophilus Infections (microbiology)
• Haemophilus influenzae (isolation & purification)
• Humans
• Infant
• Male
• Moraxella catarrhalis (isolation & purification)
• Moraxellaceae Infections (microbiology)
• Nasopharynx (drug effects, microbiology)
• Otitis Media (drug therapy, microbiology)
• Pneumococcal Infections (microbiology)
• Polymerase Chain Reaction (methods)
• Respiratory Tract Infections (drug therapy, microbiology)
• Streptococcus pneumoniae (isolation & purification)