Abstract | BACKGROUND: METHODS: RESULTS: We found positive correlation between the extent of carotid intima-media thickness (IMT) and levels of CRP (p <0.0001 in both groups) and fibrinogen (p <0.0001 in diabetics only). By multivariate analysis we searched, among all evaluated cardiovascular risk factors including markers of inflammation, for independent variables associated with carotid lesions (IMT >1.5 mm) and found in patients with hypertension a predictive role for elevated levels of CRP (OR 4.1, 95% CI 1.1-16.4, p = 0.0429), whereas in diabetics we found a predictive role for elevated levels of fibrinogen (OR 6.0, 95% CI 2.0-18.1, p = 0.0014) and CRP (OR 4.4, 95% CI 1.4-13.7, p = 0.0096). CONCLUSIONS: Recent studies have addressed the importance of therapeutic modulation of CRP and fibrinogen levels in high-risk patients for cardiovascular prevention; however, beyond the utility of these markers in the prediction of carotid lesions in subjects with newly diagnosed hypertension or diabetes, further studies are needed to evaluate the therapeutic implications in such patients.
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Authors | Egle Corrado, Manfredi Rizzo, Ida Muratori, Giuseppe Coppola, Salvatore Novo |
Journal | Archives of medical research
(Arch Med Res)
Vol. 37
Issue 8
Pg. 1004-9
(Nov 2006)
ISSN: 0188-4409 [Print] United States |
PMID | 17045118
(Publication Type: Journal Article)
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Chemical References |
- Fibrinogen
- C-Reactive Protein
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Topics |
- C-Reactive Protein
(analysis, metabolism)
- Carotid Arteries
(pathology)
- Carotid Artery Diseases
(diagnosis, etiology, pathology)
- Diabetes Mellitus, Type 2
(complications, diagnosis, metabolism)
- Fibrinogen
(analysis, metabolism)
- Humans
- Hypertension
(complications, diagnosis, metabolism)
- Tunica Media
(pathology)
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