Abstract | BACKGROUND: MATERIALS AND METHODS: Study populations of 193 patients with angiographically documented CAD, 83 patients with normal coronary angiograms (NCAD) and 55 healthy volunteers were included in the study. The patients with CAD were divided into three categories according to the number of diseased coronaries. Also, a Gensini score was calculated for each patient. Serum paraoxonase and arylesterase activities were measured spectrophotometrically. Oxidative and anti-oxidative status was evaluated by measuring serum lipid hydroperoxide (LOOH), total anti-oxidant status (TAS) and free sulfhydryl groups (-SH = total thiol). Lipid parameters were determined by routine laboratory methods. RESULTS: Serum paraoxonase and arylesterase activities, TAS and -SH levels were lower in the CAD group compared with the NCAD group and control group (P < 0.05, all). Serum LOOH levels of the CAD group were greater than those in both the control and NCAD groups (P < 0.05). The major decreases in paraoxonase, arylesterase activities, -SH and TAS levels and the major increase in LOOH levels were observed in the 3-vessels disease group. In multiple linear regression analysis, the Gensini score was independently correlated with paraoxonase activity (beta = -0.469, P < 0.001), -SH levels (beta = -0.232, P < 0.001), HDL levels and history of diabetes. CONCLUSIONS:
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Authors | M Gur, M Aslan, A Yildiz, R Demirbag, R Yilmaz, S Selek, O Erel, I Ozdogru |
Journal | European journal of clinical investigation
(Eur J Clin Invest)
Vol. 36
Issue 11
Pg. 779-87
(Nov 2006)
ISSN: 0014-2972 [Print] England |
PMID | 17032345
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Lipid Peroxides
- Carboxylic Ester Hydrolases
- arylesterase
- Aryldialkylphosphatase
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Topics |
- Aged
- Aryldialkylphosphatase
(blood)
- Biomarkers
(blood)
- Carboxylic Ester Hydrolases
(blood)
- Coronary Disease
(enzymology)
- Female
- Humans
- Lipid Peroxides
(blood)
- Male
- Middle Aged
- Oxidation-Reduction
- Spectrophotometry
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