Abstract | AIM: To assess the levels of antioxidant capacity and oxidative damage in blood of chronic pancreatitis (CP) patients in comparison with those in healthy control subjects, by using several different analytical techniques. METHODS: RESULTS: The antioxidative thiols including cysteine, cysteinylglycine and glutathione were significantly lower in CP patients. In addition, the non-enzymatic antioxidant capacity was significantly lower in CP patients, which correlated with the amount of oxidative protein ( protein carbonyls) and the extent of lipid damage ( TBARS), both were significantly higher in CP patients. The ROS production in whole blood after stimulation with phorbol 12-myritate 13-acetaat, demonstrated a strong tendency to produce more ROS in CP patients. CONCLUSION:
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Authors | Mariette Verlaan, Hennie M J Roelofs, Annie van-Schaik, Geert J A Wanten, Jan B M J Jansen, Wilbert H M Peters, Joost P H Drenth |
Journal | World journal of gastroenterology
(World J Gastroenterol)
Vol. 12
Issue 35
Pg. 5705-10
(Sep 21 2006)
ISSN: 1007-9327 [Print] United States |
PMID | 17007026
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antioxidants
- Reactive Oxygen Species
- Sulfhydryl Compounds
- Thiobarbituric Acid Reactive Substances
- Glutathione
- Cysteine
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Topics |
- Adult
- Aged
- Antioxidants
(pharmacology, therapeutic use)
- Cysteine
(blood)
- Female
- Glutathione
(blood)
- Humans
- Lipid Peroxidation
(physiology)
- Male
- Middle Aged
- Oxidative Stress
(drug effects, physiology)
- Pancreatitis, Chronic
(blood, drug therapy, physiopathology)
- Prospective Studies
- Protein Carbonylation
(physiology)
- Reactive Oxygen Species
(blood)
- Sulfhydryl Compounds
(blood)
- Thiobarbituric Acid Reactive Substances
(analysis)
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