Therapeutic application of long-circulating liposomal glucocorticoids in auto-immune diseases and cancer.

Abstract

Glucorticoids are potent drugs that have a multitude of pharmacological actions both at genomic and non-genomic levels. Many of the diseases in which glucorticoids are routinely administered are featured by angiogenesis and enhanced capillary permeability, permitting targeted delivery using long-circulating drug delivery systems. By encapsulation of glucorticoids in long-circulating liposomes, drug levels at the site of the pathology are markedly higher, increasing and prolonging therapeutic efficacy in models of rheumatoid arthritis, multiple sclerosis, and cancer.

• Authors: Raymond M Schiffelers, Manuela Banciu, Josbert M Metselaar, Gert Storm
• Journal: Journal of liposome research (J Liposome Res) Vol. 16 Issue 3 Pg. 185-94 ( 2006) ISSN: 0898-2104 [Print] England
• PMID: 16952873 (Publication Type: Journal Article)

Chemical References

• Glucocorticoids
• Liposomes

Topics

• Animals
• Autoimmune Diseases (blood)
• Glucocorticoids (administration & dosage, blood, pharmacokinetics)
• Humans
• Liposomes
• Neoplasms (blood)