Suppression of carrageenan- and collagen II-induced inflammation in mice by geranium oil.

Abstract

To obtain experimental evidence on the therapeutic efficacy of essential oils in aromatherapy for inflammatory diseases, we examined the effects of geranium oil on carrageenan-induced and collagen II-induced inflammation in mice, to assess acute and chronic anti-inflammatory activities of the oil. Single intraperitoneal injection of 5 mu L of geranium oil clearly suppressed the carrageenan-induced footpaw edema and increase in tissue myeloperoxidase activity, and repeated administration of the oil suppressed collagen-induced arthritis. These results revealed that geranium oil suppressed both acute and chronic inflammatory responses in mice.

• Authors: Naho Maruyama, Hiroko Ishibashi, Weimin Hu, Shinichiro Morofuji, Shigeharu Inouye, Hideyo Yamaguchi, Shigeru Abe
• Journal: Mediators of inflammation (Mediators Inflamm) Vol. 2006 Issue 3 Pg. 62537 ( 2006) ISSN: 0962-9351 [Print] United States
• PMID: 16951493 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Collagen Type II
• Oils, Volatile
• Carrageenan
• Peroxidase

Topics

• Animals
• Arthritis, Experimental (prevention & control)
• Carrageenan
• Collagen Type II (immunology)
• Geranium
• Inflammation (prevention & control)
• Male
• Mice
• Mice, Inbred DBA
• Oils, Volatile (therapeutic use)
• Peroxidase (metabolism)