Abstract | BACKGROUND: AIMS: METHODS: Six rabbits were treated with dexamethasone phosphate 0.1% in the right eye and with NCX1021 in the left eye for 5 weeks. The parameters considered were IOP, nitric oxide marker levels in aqueous humour, ocular haemodynamics of ophthalmic artery (by means of colour Doppler imaging), expression of endothelial nitric oxide synthase (eNOS)in ciliary processes and histology of ciliary bodies. RESULTS: CONCLUSIONS:
NCX1021 may avoid the IOP increase, impairment of ocular blood flow and the morphological changes in the ciliary bodies possibly induced by corticosteroid treatment.
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Authors | F Galassi, E Masini, B Giambene, F Fabrizi, C Uliva, M Bolla, E Ongini |
Journal | The British journal of ophthalmology
(Br J Ophthalmol)
Vol. 90
Issue 11
Pg. 1414-9
(Nov 2006)
ISSN: 0007-1161 [Print] England |
PMID | 16914472
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Glucocorticoids
- NCX1021
- Nitric Oxide Donors
- Nitrites
- dexamethasone 21-phosphate
- Nitric Oxide
- Dexamethasone
- Nitric Oxide Synthase Type III
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Topics |
- Animals
- Aqueous Humor
(chemistry)
- Blotting, Western
(methods)
- Ciliary Body
(chemistry, drug effects)
- Dexamethasone
(analogs & derivatives, chemistry, pharmacology)
- Glaucoma
(drug therapy, metabolism)
- Glucocorticoids
(pharmacology)
- Intraocular Pressure
(drug effects)
- Male
- Models, Animal
- Nitric Oxide
(metabolism)
- Nitric Oxide Donors
(pharmacology)
- Nitric Oxide Synthase Type III
(analysis)
- Nitrites
(analysis)
- Ophthalmic Artery
(drug effects)
- Rabbits
- Vascular Resistance
(drug effects)
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