Vinorelbine-based chemotherapy in hormone-refractory prostate cancer.

Abstract

BACKGROUND:

No consensus exists regarding further therapy for the management of hormone-refractory prostate cancer. In this phase II study, the combination of Vinorelbine with 5-Fluorouracil and folinic acid (FLN regimen) was evaluated in patients with progressive or resistant disease after hormone therapy.

PATIENTS AND METHODS:

Thirty-four patients were treated with Vinorelbine at a dose of 20 mg/m2 intravenously (i.v.) on days 1 and 3, folinic acid (FA), 100 mg/m2 i.v. and 5-Fluorouracil (5-FU), 350 mg/m2 i.v. as a short infusion on days 1 to 3. The therapy was given in an out-patient setting, every 3 weeks.

RESULTS:

All of the 34 eligible patients were evaluable for toxicity and 30 for activity. A total of 127 cycles was administered (91% at full dose). Among thelS5 patients with measurable disease, four had a partial response (26.6%; C.I. 95%, 28.3% to 65.7%) and four achieved stable disease. In 14 patients (47%) a clinical benefit was documented. Six out of 15 patients with bone-only involvement had stable disease (40%). The median duration of stabilization and partial response was 16 weeks (range 4-24 weeks). The most common toxicity was hematological: Grade 4 (NCI-CTC scale) in five patients at re-cycle. Other toxicities were of low incidence and easy to manage.

CONCLUSION:

The encouraging results obtained with the FLN regimen in terms of clinical benefit and its predictable and manageable toxicity support the palliative role of this chemotherapeutic strategy in hormone-refractory prostate patients.

• Authors: M G Zampino, E Verri, M Locatelli, G Curigliano, G Ascione, A Sbanotto, A Rocca, F Verweij, V Matei, E Scardino, O Decobelli, A Goldhirsch, F Nolè
• Journal: Anticancer research (Anticancer Res) 2006 May-Jun Vol. 26 Issue 3B Pg. 2375-80 ISSN: 0250-7005 [Print] Greece
• PMID: 16821619 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Antineoplastic Agents, Hormonal
• Vinblastine
• Leucovorin
• Vinorelbine
• Fluorouracil

Topics

• Adenocarcinoma (drug therapy)
• Aged
• Antineoplastic Agents, Hormonal (pharmacology)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Drug Administration Schedule
• Drug Resistance, Neoplasm
• Fluorouracil (administration & dosage)
• Humans
• Leucovorin (administration & dosage)
• Male
• Middle Aged
• Prostatic Neoplasms (drug therapy)
• Vinblastine (administration & dosage, analogs & derivatives)
• Vinorelbine