The effect of conventional and sustained delivery of thymoquinone and levodopa on SH-SY5Y human neuroblastoma cells.

Abstract

The objective of this study was to determine the effects of thymoquinone on the viability and metabolic activity of SH-SY5Y human neuroblastoma cells alone or challenged with levodopa (L-dopa) using conventional and sustained drug delivery routes. The findings suggest that thymoquinone may protect SH-SY5Y cells against L-dopa toxicity to some degree although the exact mechanism for this is unknown. Thymoquinone may be a viable option to prevent quinone formation as a result of L-dopa auto-oxidation and could be investigated as a neuroprotective agent given the fact that inflammatory etiologies are strongly implemented in the pathogenesis of Parkinson's disease.

• Authors: Tina Mitchell Martin, Hamed Benghuzzi, Michelle Tucci
• Journal: Biomedical sciences instrumentation (Biomed Sci Instrum) Vol. 42 Pg. 332-7 ( 2006) ISSN: 0067-8856 [Print] United States
• PMID: 16817630 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antiparkinson Agents
• Benzoquinones
• Delayed-Action Preparations
• Drug Combinations
• Neuroprotective Agents
• Levodopa
• Hydrogen Peroxide
• thymoquinone

Topics

• Antiparkinson Agents (administration & dosage)
• Benzoquinones (administration & dosage)
• Cell Line, Tumor
• Cell Survival (drug effects)
• Delayed-Action Preparations (administration & dosage)
• Dose-Response Relationship, Drug
• Drug Combinations
• Humans
• Hydrogen Peroxide (metabolism)
• Levodopa (administration & dosage)
• Neuroblastoma (drug therapy, metabolism, pathology)
• Neuroprotective Agents (administration & dosage)
• Treatment Outcome