S-Allylcysteine prevents the rat from 3-nitropropionic acid-induced hyperactivity, early markers of oxidative stress and mitochondrial dysfunction.

Abstract	We investigated the effects of S-allylcysteine (SAC) on early behavioral alterations, striatal changes in superoxide dismutase (SOD) activity, lipid peroxidation (LP) and mitochondrial dysfunction induced by the systemic infusion of 3-nitropropionic acid (3-NPA) to rats. SAC (300 mg/kg, i.p.), given to animals 30 min before 3-NPA (30 mg/kg, i.p.), prevented the hyperkinetic pattern evoked by the toxin. In addition, 3-NPA alone produced decreased activities of manganese- (Mn-SOD) and copper/zinc-dependent superoxide dismutase (Cu,Zn-SOD), increased LP (evaluated as the formation of lipid fluorescent products) and produced mitochondrial dysfunction in the striatum (measured as decreased 3-(3,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reduction). In contrast, pretreatment of 3-NPA-injected rats with SAC resulted in a significant prevention of all these markers. Our findings suggest that the protective actions of SAC are related with its antioxidant properties, which in turn may be accounting for the preservation of SOD activity and primary mitochondrial tasks.
Authors	María N Herrera-Mundo, Daniela Silva-Adaya, Perla D Maldonado, Sonia Galván-Arzate, Leticia Andrés-Martínez, Verónica Pérez-De La Cruz, José Pedraza-Chaverrí, Abel Santamaría
Journal	Neuroscience research (Neurosci Res) Vol. 56 Issue 1 Pg. 39-44 (Sep 2006) ISSN: 0168-0102 [Print] Ireland
PMID	16806549 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antineoplastic Agents Biomarkers Convulsants Isoenzymes Nitro Compounds Propionates S-allylcysteine Superoxide Dismutase Cysteine 3-nitropropionic acid
Topics	Akathisia, Drug-Induced Animals Antineoplastic Agents (metabolism) Behavior, Animal (drug effects) Biomarkers (metabolism) Convulsants (pharmacology) Corpus Striatum (drug effects, metabolism) Cysteine (analogs & derivatives, metabolism) Isoenzymes (metabolism) Lipid Peroxidation Male Mitochondria (metabolism) Nitro Compounds (pharmacology) Oxidative Stress Propionates (pharmacology) Psychomotor Agitation Rats Rats, Wistar Superoxide Dismutase (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!