Glucose-induced insulin response is reduced and proinsulin response increased in healthy siblings of type 1 diabetic patients.
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| Abstract |
Glucose-stimulated insulin and proinsulin responses, and insulin sensitivity, were studied in 30 HLA identical, 38 HLA haplo-identical, and 25 HLA non-identical, healthy islet-cell-antibody negative siblings of Type 1 diabetic patients. The results were compared with 41 age- and sex-matched healthy subjects with no diabetes in the family. The proinsulin-corrected insulin response to an intravenous glucose infusion test was significantly lower among siblings when insulin sensitivity was taken into account (1.65 (inter-quartile range 1.20-2.64) vs 2.18 (1.65-3.28) nmol mmol-1 min, p = 0.04). Proinsulin values were consistently higher among siblings than among control subjects (peak values 50.0 vs 38.0 pmol l-1 (p = 0.004)). When proinsulin release was corrected for individual insulin sensitivity this difference remained. The results suggest disturbed islet B-cell function, unrelated to HLA identity or the presence of circulating islet cell antibodies.
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| Authors | F A Lindgren, S G Hartling, G G Dahlquist, C Binder, S Efendić, B E Persson |
| Journal | Diabetic medicine : a journal of the British Diabetic Association (Diabet Med) 1991 Aug-Sep Vol. 8 Issue 7 Pg. 638-43 ISSN: 0742-3071 [Print] England |
| PMID | 1680601 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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