Long-term remissions in patients with myelodysplastic syndrome and secondary acute myelogenous leukemia undergoing allogeneic transplantation following a reduced intensity conditioning regimen of 550 cGy total body irradiation and cyclophosphamide.

Abstract

We analyzed outcomes of patients with myelodysplastic syndrome (MDS) or secondary acute myelogenous leukemia (sAML) that were treated at our institution with a reduced intensity conditioning (RIC) regimen of 550-cGy total body irradiation and cyclophosphamide followed by related donor (RD) or unrelated donor (URD) transplantation. Fifty-one consecutive patients with MDS or sAML received this RIC regimen and URD (n = 30) or RD (n = 21) stem cells. Graft-versus-host disease prophylaxis consisted of cyclosporine alone (RD) or with corticosteroids and methotrexate (URD). Median patient age was 44 years. With a median follow-up of 3.7 years after transplantation in the 19 surviving patients (37%), Kaplan-Meier estimates of overall survival were 88%, 46%, 33%, and 11% for patients transplanted with sAML in remission, refractory anemia, refractory anemia with excess blasts, refractory anemia with excess blasts in transformation, or sAML refractory/untreated, respectively. Kaplan-Meier estimates of relapse-free survival were 75%, 46%, 33%, and 11%, respectively. Overall, the cumulative incidences of relapse and transplant-related mortality were 27% and 37%, respectively. In patients with MDS, this is an effective RIC regimen for allogeneic transplantation that can be used as an alternative to other RIC or conventional conditioning regimens.

• Authors: Christopher L Hallemeier, Mark D Girgis, William G Blum, Randy A Brown, Hanna J Khoury, Steven M Devine, Ravi Vij, Hsu-san Lin, John F DiPersio, Douglas R Adkins
• Journal: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation (Biol Blood Marrow Transplant) Vol. 12 Issue 7 Pg. 749-57 (Jul 2006) ISSN: 1083-8791 [Print] United States
• PMID: 16785064 (Publication Type: Journal Article)

Chemical References

• Myeloablative Agonists
• Cyclophosphamide

Topics

• Adult
• Aged
• Analysis of Variance
• Bone Marrow Transplantation (methods, mortality)
• Cyclophosphamide (therapeutic use)
• Female
• Graft Survival
• Graft vs Host Disease (etiology)
• Humans
• Leukemia, Myeloid, Acute (therapy)
• Male
• Middle Aged
• Myeloablative Agonists (therapeutic use)
• Myelodysplastic Syndromes (therapy)
• Neoplasms, Second Primary (therapy)
• Peripheral Blood Stem Cell Transplantation (methods, mortality)
• Radiotherapy Dosage
• Recurrence
• Retrospective Studies
• Survival Analysis
• Transplantation Conditioning (methods)
• Whole-Body Irradiation (methods)