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Homologous Transplantation (Allograft)

Subscribe to New Research on Homologous Transplantation

Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.

Also Known As:

Allograft; Homograft; Transplantation, Homologous; Allogeneic Transplantation; Allogeneic Transplantations; Allografts; Homografts; Homologous Transplantations; Transplantations, Allogeneic; Transplantations, Homologous; Transplantation, Allogeneic

Networked: 17258 relevant articles (755 outcomes, 1339 trials/studies)

Relationship Network

Therapy Context: Research Results

Operative Surgical Procedures: 8
- Transplantation: 55694
  - Homologous Transplantation: 17258
    - Isogeneic Transplantation: 412

Experts

1.	Haberal, M: 28 articles (05/2015 - 03/2000)
2.	Ayerza, Miguel A: 25 articles (12/2015 - 05/2004)
3.	Robbins, Robert C: 25 articles (09/2011 - 02/2002)
4.	Muscolo, D Luis: 22 articles (12/2015 - 05/2004)
5.	Legendre, Christophe: 21 articles (11/2015 - 01/2002)
6.	Lazarus, Hillard M: 21 articles (09/2015 - 12/2004)
7.	Razonable, Raymund R: 21 articles (09/2014 - 10/2002)
8.	Lemström, Karl B: 21 articles (05/2013 - 02/2002)
9.	Malyszko, J: 20 articles (01/2013 - 09/2003)
10.	Mohanakumar, T: 20 articles (12/2012 - 01/2000)

Related Diseases

1.	Infection 05/01/2010 - "Organ transplantation has proven to be an effective therapeutic for a wide variety of disease states, but the chronic immunosuppression required for allograft survival increases the risk for infection and neoplasia. " 01/01/2008 - "Transplantation of allogeneic organs has proven to be an effective therapeutic for a large variety of disease states, but the chronic immunosuppression that is required for organ allograft survival increases the risk for infection and neoplasia and has direct organ toxicity. " 02/01/1993 - "Although complete protection against persistent or recurrent infection has not been achieved and late deterioration may be expected, in situ allograft replacement seems to be a major advance in the management of infected infrarenal aortic prosthetic grafts." 08/01/1985 - "These data suggest that a significant reduction in morbidity and possibly mortality could be accomplished by complete eradication of infection prior to allograft nephrectomy. " 01/01/2014 - "The addition of extracorporeal photopheresis (ECP) to a standard immunosuppressive drug therapy after heart transplantation in clinical studies has shown to be beneficial, for example, by reducing acute rejection, allograft vasculopathy or CMV infection. "
2.	Neoplasms (Cancer) 12/01/2015 - "To the best of our knowledge, this is the first case in which a donor-transmitted tumor was diagnosed in the renal allograft only 4 days after transplantation and subsequently treated successfully with radiofrequency ablation." 06/01/2013 - "A combination of AIP-1 + AIP-2 was most effective in reducing the tumor allograft incidence. " 08/27/2003 - "The best treatment-withdrawal or reduction of immunosuppression-permits tumor rejection but risks allograft rejection. " 05/28/1996 - "While systemic tumor control was improved by systematic chemotherapy, local tumor control was improved by appropriate biopsy techniques, and amputations have been replaced by local resections, in most cases with reconstruction (arthrodesis, rotation plasty, endoprosthesis, allografts), which require further improvements. " 01/01/2012 - "The in vivo study demonstrated that SLE has marked antitumor efficacy against tumors in the WEHI-3 cell allograft model. "
3.	Leukemia 02/01/1995 - "Whereas immunomagnetic CD34+ selection is most effective in terms of elimination of T cells, the less intensive T and NK cell depletions achieved with CAMPATH-1 might be advantageous with regard to retaining engraftment potential and graft-vs.-leukemia (GVL) activity of PBPC allografts." 10/01/1988 - "Allogeneic transplantation versus intensive chemotherapy in first-remission acute leukemia: is there a "best choice"?" 02/14/2013 - "Often, the strategy is proposed of treating patients with relapsed leukemia into a second remission (CR2) and then proceeding to allogeneic transplantation as the definitive curative approach. " 11/01/2001 - "Allogeneic transplantation has been demonstrated to be effective with a strong suggestion of graph versus leukemia effect. " 07/01/1999 - "We conclude that patients with acute leukemia who are alive and well without chronic GVHD two years following an allograft have a high probability of being cured, whereas patients with active chronic GVHD requiring immunosuppression continue to be at risk of non-relapse death. "
4.	Autoimmune Diseases (Autoimmune Disease) 01/01/2006 - "FTY is highly effective in prolonging allograft survival in preclinical models of transplantation and in experimental models of autoimmune diseases. " 12/01/2009 - "Altering the immunosuppressive regimen to modify T-cell dysregulation may be beneficial for patients who develop post-transplant autoimmune disease and allow continued preservation of allograft." 01/01/2005 - "Immunosuppressive drugs have improved the therapeutic management of allograft organ transplantation and autoimmune diseases, significantly. " 10/01/1993 - "The introduction of CsA in the early 1970's significantly improved the outcome of organ and bone marrow allograft transplantation and advanced therapeutic options in autoimmune diseases. " 07/27/2001 - "If mixed chimerism can be achieved safely with novel low-intensity conditioning regimens and results in sustained remission of autoimmune diseases, allogeneic transplantation may become a realistic therapy in the management of some patients with autoimmune disease."
5.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 02/01/2015 - "Is allogeneic transplantation really the best treatment for FLT3/ITD-positive acute myeloid leukemia? " 08/01/2001 - "It has been widely accepted that patients in first remission of acute myeloid leukemia (AML) with a donor should receive an allograft, and many also believe that autologous transplantation is the next best option. " 06/01/2013 - "This study was conducted to retrospectively compare the clinical outcomes after transplantation of T cell-depleted (TCD) and unmodified allografts in patients with acute myeloid leukemia (AML) in first complete remission (CR1). " 02/01/2012 - "Classifying cytogenetics in patients with acute myelogenous leukemia in complete remission undergoing allogeneic transplantation: a Center for International Blood and Marrow Transplant Research study." 04/01/2014 - "Benefit of allogeneic transplantation in patients age ≥ 60 years with acute myeloid leukemia is limited to those in first complete remission at time of transplant."

Related Drugs and Biologics

1.	Cyclosporine (Ciclosporin)
2.	Sirolimus (Rapamycin)
3.	Lamivudine (3TC)
4.	mycophenolate mofetil (Cellcept)
5.	Monoclonal Antibodies
6.	fludarabine
7.	Calcineurin
8.	Antigens
9.	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)
10.	fingolimod (FTY720)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Transplantation (Transplant Recipients)
3.	Homologous Transplantation (Allograft)
4.	Kidney Transplantation
5.	Drug Therapy (Chemotherapy)