[Cell therapy in treatment of trophic ulcers of lower extremities].

Abstract

The aim of the work was to study the effectiveness of using human embryo fibroblast culture in complex treatment of trophic ulcers of venous etiology in 23 patients with trophic ulcers of lower extremities. The cause of the appearance of ulcers was postthrombophlebitic disease in 16 patients and varicose disease in 7 patients. A control group consisted of 25 patients (postthrombophlebitic disease in 18 patients and varicose disease in 7 patients). The human embryo cell culture grown on the wound cover "Foliderm" was used at the stage of epithelization in the main group, while in the control group the modern alginate, collagen, hydrogel, polyurethane and hydrocolloid covers Suprosorb--Suprosorb A, Suprosorb C, Suprosorb G, Suprosorb F and Suprosorb H were used. Healing of the varicose trophic ulcers in the control group was achieved in 86% of patients, of post-thrombophlebitic--in 78% of patients. The average period of healing was 3.6 and 3.9 months respectively. Healing of trophic ulcers in the main group took place in 100% of patients. The average period of healing was 1.5 week for varicose and 3.2 weeks for postthrombophlebitic ulcers. The cell therapy was shown to be a highly effective method in treatment of venous trophic ulcers.

• Authors: V M Sedov, D Iu Andreev, T D Smirnova, B A Paramonov, T N En'kina, A A Sominina, O I Kiselev, Iu Iu Suissi, L V Lebedev
• Journal: Vestnik khirurgii imeni I. I. Grekova (Vestn Khir Im I I Grek) Vol. 165 Issue 2 Pg. 90-4 ( 2006) ISSN: 0042-4625 [Print] Russia (Federation)
• PMID: 16752648 (Publication Type: Comparative Study, English Abstract, Journal Article)

Topics

• Cell- and Tissue-Based Therapy (methods)
• Cells, Cultured
• Female
• Fibroblasts (cytology, transplantation)
• Humans
• Leg Ulcer (pathology, therapy)
• Male
• Middle Aged
• Stem Cell Transplantation (methods)
• Time Factors
• Treatment Outcome
• Wound Healing