Abstract | OBJECTIVE: DESIGN: Multicenter, open-label treatment phase followed by double-blind, randomized, parallel-group maintenance phase. SETTING: Ambulatory patients in research or referral centers. PATIENTS: Volunteer sample of 189 patients with moderately severe to severe acne vulgaris (110 entered maintenance phase, 90 completed, and 2 discontinued because of adverse events). INTERVENTIONS: MAIN OUTCOME MEASURES: Overall disease severity, global improvement, and lesion counts. RESULTS: All regimens were effective in sustaining improvements in acne. After 12 weeks of maintenance therapy, the mean reductions from baseline in noninflammatory and inflammatory lesion count, respectively, were 60% and 54% with tazarotene, 52% and 66% with minocycline, and 64% and 66% with tazarotene plus minocycline. At week 24, more than 80% of patients in each group had maintained a 50% or greater global improvement from baseline, and more than 50% had maintained a 75% or greater global improvement. CONCLUSIONS: A high percentage of patients with moderately severe to severe acne can maintain improvement in their condition with topical retinoid monotherapy. Maintenance with combination tazarotene and minocycline therapy showed a trend for greater efficacy but no statistical significance vs tazarotene alone. Topical retinoid monotherapy should be considered for maintenance to help minimize antibiotic exposure.
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Authors | James Leyden, Diane M Thiboutot, Alan R Shalita, Guy Webster, Kenneth Washenik, Bruce E Strober, Jerome Shupack |
Journal | Archives of dermatology
(Arch Dermatol)
Vol. 142
Issue 5
Pg. 605-12
(May 2006)
ISSN: 0003-987X [Print] United States |
PMID | 16702498
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Dermatologic Agents
- Nicotinic Acids
- tazarotene
- Minocycline
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Topics |
- Acne Vulgaris
(drug therapy, pathology)
- Administration, Oral
- Adult
- Anti-Bacterial Agents
(administration & dosage, therapeutic use)
- Dermatologic Agents
(administration & dosage, therapeutic use)
- Double-Blind Method
- Drug Administration Schedule
- Female
- Humans
- Male
- Minocycline
(administration & dosage, therapeutic use)
- Nicotinic Acids
(administration & dosage, therapeutic use)
- Severity of Illness Index
- Treatment Outcome
- United States
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