Abstract | BACKGROUND & AIMS: METHODS: Two-hundred forty-one consecutive patients with cirrhosis submitted to liver transplantation during a 4-year period (January 2000-December 2003) were included in the study. The main end point was survival at 3 months after transplantation. Secondary end points were complications within the first month after transplantation. RESULTS: Patients with hyponatremia (serum sodium lower than 130 mEq/L) had a greater incidence of neurologic disorders, renal failure, and infectious complications than patients without hyponatremia (odds ratio; 4.6, 3.4 and 2.7, respectively) within the first month after transplantation. By contrast, hyponatremia was not associated with an increased incidence of severe intra-abdominal bleeding, acute rejection, or vascular and biliary complications. Hyponatremia was an independent predictive factor of early posttransplantation survival. Three-month survival of patients with hyponatremia was 84% compared with 95% of patients without hyponatremia (P < .05). Survival was similar after 3 months. CONCLUSIONS:
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Authors | Maria-Carlota Londoño, Mónica Guevara, Antoni Rimola, Miquel Navasa, Pilar Taurà, Antoni Mas, Juan-Carlos García-Valdecasas, Vicente Arroyo, Pere Ginès |
Journal | Gastroenterology
(Gastroenterology)
Vol. 130
Issue 4
Pg. 1135-43
(Apr 2006)
ISSN: 0016-5085 [Print] United States |
PMID | 16618408
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Adult
- Aged
- Female
- Humans
- Hyponatremia
(complications, etiology)
- Infections
(epidemiology)
- Liver Cirrhosis
(blood, surgery)
- Liver Transplantation
(adverse effects, mortality)
- Male
- Middle Aged
- Nervous System Diseases
(epidemiology)
- Postoperative Complications
(epidemiology)
- Predictive Value of Tests
- Renal Insufficiency
(epidemiology)
- Risk Factors
- Survival Analysis
- Treatment Outcome
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