Botulinum toxin A relieved neuropathic pain in a case of post-herpetic neuralgia.

Abstract

Botulinum toxin type A (BTX-A) has been widely used in many clinical disorders including migraine, cervical dystonia, etc. The use of BTX-A in neuropathic pain, however, is uncommon, and the application of the anti-nociceptive effect of botulinum toxin is emerging. Here we report a case of an 80-year-old man who suffered from severe pain of post-herpetic neuralgia which was refractory to the usual therapies. However, this neuropathic pain was dramatically relieved by multiple BTX-A injection and the pain relief lasted 52 days.

• Authors: Hsu-Tang Liu, Shen-Kou Tsai, Ming-Chang Kao, Jenkin S Hu
• Journal: Pain medicine (Malden, Mass.) (Pain Med) 2006 Jan-Feb Vol. 7 Issue 1 Pg. 89-91 ISSN: 1526-2375 [Print] England
• PMID: 16533208 (Publication Type: Case Reports, Journal Article)

Chemical References

• Amines
• Analgesics
• Analgesics, Opioid
• Cyclohexanecarboxylic Acids
• Neurotoxins
• Amitriptyline
• gamma-Aminobutyric Acid
• Gabapentin
• Botulinum Toxins, Type A
• Acetylcholine

Topics

• Acetylcholine (metabolism)
• Aged, 80 and over
• Amines (therapeutic use)
• Amitriptyline (therapeutic use)
• Analgesics (therapeutic use)
• Analgesics, Opioid (therapeutic use)
• Botulinum Toxins, Type A (administration & dosage, adverse effects)
• Cyclohexanecarboxylic Acids (therapeutic use)
• Drug Administration Schedule
• Gabapentin
• Herpes Zoster (complications)
• Humans
• Injections, Subcutaneous
• Intercostal Nerves (drug effects, physiopathology)
• Male
• Nerve Fibers, Unmyelinated (drug effects, physiology)
• Neuralgia (drug therapy, physiopathology, virology)
• Neurons, Afferent (drug effects, physiology)
• Neurotoxins (therapeutic use)
• Nociceptors (drug effects, physiopathology)
• Skin (innervation, physiopathology)
• Synaptic Transmission (drug effects, physiology)
• Treatment Outcome
• gamma-Aminobutyric Acid (therapeutic use)