Abstract |
Photosensitizing drugs that can damage cellular biomolecules is a matter of concern. Lomefloxacin, norfloxacin, ofloxacin, and enoxacin (broad-spectrum antibiotics of fluoroquinolone group) are used for the treatment of Gram-positive and Gram-negative bacterial infections. Phototoxicity and possible mechanism of their action was assessed under the exposure of ambient levels of UV-A, UV-B, and sunlight at a concentration generally used in the treatment of various diseases. Singlet oxygen (1O2), superoxide anion radical (O2.-) generation, DNA damage, and lipid peroxidation in human blood were studied. All the fluoroquinolones tested in this study produced 1O2 and O2.- under exposure to UV-A, UV-B, and sunlight depending on the concentrations (0 to 60 microg/mL) of the drugs. Enoxacin showed a higher yield of 1O2 and O2.- than other drugs. These materials also degraded deoxyguanosine and induced lipid peroxidation in vitro under exposure to UV-A, UV-B, and sunlight (depending on the dose of radiation). The formation of the reactive oxygen species (ROS) by the photoexcited drugs may be considered as a possible mechanism of their action.
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Authors | R S Ray, N Agrawal, R B Misra, M Farooq, R K Hans |
Journal | Drug and chemical toxicology
(Drug Chem Toxicol)
Vol. 29
Issue 1
Pg. 25-38
(Jan 2006)
ISSN: 0148-0545 [Print] United States |
PMID | 16455588
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Anti-Infective Agents
- Fluoroquinolones
- Photosensitizing Agents
- Superoxides
- Singlet Oxygen
- DNA
- Deoxyguanosine
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Topics |
- Anti-Bacterial Agents
- Anti-Infective Agents
(toxicity)
- Blood
(drug effects, metabolism)
- DNA
(drug effects)
- DNA Damage
- Deoxyguanosine
(metabolism)
- Dose-Response Relationship, Drug
- Fluoroquinolones
(toxicity)
- Humans
- Lipid Peroxidation
- Photosensitizing Agents
(toxicity)
- Singlet Oxygen
(metabolism)
- Superoxides
(metabolism)
- Ultraviolet Rays
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