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Ofloxacin (Levofloxacin)

A synthetic fluoroquinolone (FLUOROQUINOLONES) antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.

Also Known As:

Levofloxacin; Levaquin; Ofloxacine; Quixin; DL-8280; DR-3355; Hoe-280; ORF-28489; Ofloxacin Hydrochloride; Ofloxacin, (S)-Isomer; Ru-43280; Tarivid; DL 8280; DL8280; DR 3355; DR3355; Hoe 280; Hoe280; ORF 28489; ORF28489; Ru 43280; Ru43280; (+/-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7- -oxo-7H-pyrido(1,2,3-de)- -1,4-benzoxazine-6-carboxylic acid

Networked: 2982 relevant articles (495 outcomes, 561 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- 2-Ring Heterocyclic Compounds
  - Quinolines: 92
    - Quinolones: 1190
      - Fluoroquinolones: 2005
        Ofloxacin: 2982
        antofloxacin: 4
        desmethylofloxacin: 2
        ofloxacin N-oxide: 2
        3-fluoromethyl ofloxacin
        ofloxacin O-glucuronide
        ofloxacin pivaloyloxymethyl ester
        R 71762

Experts

1.	Kahn, James B: 13 articles (06/2010 - 08/2002)
2.	Nicolau, David P: 10 articles (11/2015 - 04/2004)
3.	Tennenberg, Alan M: 10 articles (12/2006 - 09/2003)
4.	Zhanel, George G: 9 articles (04/2012 - 01/2002)
5.	Noel, Gary J: 8 articles (07/2014 - 02/2005)
6.	Pea, Federico: 8 articles (12/2009 - 01/2003)
7.	Dudley, Michael N: 7 articles (07/2015 - 05/2006)
8.	Arakawa, Soichi: 7 articles (04/2014 - 03/2004)
9.	Naber, K G: 7 articles (05/2011 - 05/2000)
10.	Furlanut, Mario: 7 articles (04/2009 - 01/2003)

Related Diseases

1.	Infection 02/01/1987 - "Ofloxacin proved to be extremely effective in curing experimental infections induced by both gram-positive and gram-negative pathogens." 01/01/1986 - "On the basis of these preliminary results, ofloxacin can be considered as a highly efficient oral substance which is effective against Staphylococcus aureus and Pseudomonas aeruginosa, two important pathogens in inflammatory ear infections." 08/15/2002 - "This study tested whether levofloxacin, at a new high dose of 750 mg, was effective for the treatment of complicated skin and skin-structure infections (SSSIs). " 10/01/2013 - "After diagnosis of septic gonarthritis due to Sphingomonas paucimobilis, the infection was successfully treated by oral antibiotic therapy with ofloxacine based on the patient's antibiotic susceptibility profile, combined with analgesic and anti-inflammatory local physical therapy several times a day leading to a considerable improvement in the symptoms so that operative interventions could therefore be avoided. " 01/01/2004 - "High-dose levofloxacin is able to exploit these pharmacokinetic features to provide an effective treatment for severe infections. "
2.	Pneumonia (Pneumonitis) 01/01/1992 - "Intravenous followed by oral ofloxacin was highly effective in many difficult cases of pneumonia." 11/01/2003 - "Levofloxacin has improved anti-gram-positive potency, PK/PD properties, a proven clinical trial record (particularly for communityacquired pneumonia [CAP]), and an excellent safety profile-in the context of the treatment of >250 million patients worldwide in the past decade. " 09/01/2002 - "We conclude that levofloxacin is effective against experimental pneumonia due to pneumococci with MIC < 1.5 mg/L, ineffective on experimental pneumonia due to pneumococci with MIC > or = 2 mg/L, and could be associated with the appearance of mutants when a parC mutation is pre-existing." 07/01/1998 - "In experimental pneumonia in guinea pigs, in which the biofilm mode of growth of the strain was observed in the lung, only levofloxacin exhibited substantial therapeutic efficacy. " 05/01/1996 - "When given as monotherapy for the empiric treatment of community-acquired pneumonia, ofloxacin is as effective as standard antimicrobial therapy."
3.	Urinary Tract Infections (Urinary Tract Infection) 01/01/1996 - "In the treatment of patients with noncomplicated urinary tract infection good results (the clinical and bacteriological efficacies of 96 and 88 per cent respectively) were observed when ofloxacin was used orally in a single dose of not more than 400 mg once a day for 3 to 5 days. " 03/01/2003 - "These study results indicate that levofloxacin 250 mg orally once daily for 10 days is an effective and well tolerated treatment of complicated urinary tract infections." 08/01/1987 - "This study showed that Ofloxacin is effective against urinary tract infections." 01/01/1988 - "The clinical efficacy of the new quinolone antibacterial agent ofloxacin (OFLX) on urinary tract infections (UTI) was reevaluated. " 01/01/1993 - "The efficacy of single dose ofloxacin in lower urinary tract infections was investigated in this study. "
4.	Respiratory Tract Infections (Respiratory Tract Infection) 01/01/1991 - "Ofloxacin is a proven antibiotic substance useful in the treatment of lower respiratory tract infections." 07/20/2005 - "500 mg once daily of levofloxacin was expected to be effective for the treatment of respiratory tract infections caused by S. " 01/01/1987 - "In 535 cases with lower respiratory infections, ofloxacin was effective in 78.1%. " 06/01/1999 - "These in-vitro results suggest that levofloxacin may be useful in the treatment of community-acquired lower respiratory tract infections." 01/01/1992 - "Our data indicate that ofloxacin is effective and safe as specific and empiric treatment for many lower respiratory tract infections."
5.	Typhoid Fever (Typhoid) 04/01/1995 - "A 3-day course of ofloxacin proved to be safe and highly effective in the treatment of uncomplicated, multidrug-resistant typhoid fever." 09/01/1994 - "Ofloxacin was found to be well tolerated and effective in treating typhoid fever." 01/01/1990 - "Ofloxacin was well tolerated and appears to be an effective agent in the treatment of typhoid fever." 01/01/1988 - "Ofloxacin was particularly effective in the treatment of enteric fever in 35 patients; eradication was achieved in all of them; 34 patients were clinically cured within 4 days, however, one patient with bacteraemia due to Salmonella paratyphi A subsequently died, due to his underlying disorder. " 01/01/1986 - "Ofloxacin was also effective in the treatment of enteric fever, in which eradication was achieved in all seven patients. "

Related Drugs and Biologics

1.	Ciprofloxacin (Cipro)
2.	Rifampin (Rifampicin)
3.	Ofloxacin (Levofloxacin)
4.	moxifloxacin (Avelox)
5.	Fluoroquinolones
6.	Anti-Bacterial Agents (Antibiotics)
7.	Norfloxacin
8.	Azithromycin (Zithromax)
9.	Clarithromycin (Biaxin)
10.	Amoxicillin (Wymox)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Oral Administration
3.	Middle Ear Ventilation (Tympanostomy)
4.	Transplants (Transplant)
5.	Aftercare (After-Treatment)