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Norfloxacin

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A synthetic fluoroquinolone (FLUOROQUINOLONES) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA GYRASE.

Also Known As:

AM-0715; AM-715; MK-0366; MK-366; MK0366; MK366; Merck Brand of Norfloxacin; Noroxin; AM 0715; AM 715; AM0715; MK 0366; MK 366; Norfloxacin Merck Brand; 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-

Networked: 743 relevant articles (129 outcomes, 156 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Francés, Rubén: 8 articles (11/2015 - 09/2006)
2.	Such, José: 8 articles (11/2015 - 09/2006)
3.	Zapater, Pedro: 8 articles (11/2015 - 09/2006)
4.	Fernández, Javier: 6 articles (05/2012 - 01/2002)
5.	González-Navajas, José M: 5 articles (01/2015 - 09/2006)
6.	Navasa, Miquel: 5 articles (03/2012 - 01/2002)
7.	Pérez-Mateo, Miguel: 5 articles (03/2011 - 09/2006)
8.	Pascual, Sonia: 5 articles (03/2011 - 09/2006)
9.	Mamdani, Muhammad M: 4 articles (03/2015 - 04/2010)
10.	Juurlink, David N: 4 articles (03/2015 - 04/2010)

Related Diseases

1.	Infection 01/01/1988 - "In 12 recent clinical studies, norfloxacin given in various dosage regimens was shown to be highly effective in treating 1,588 gonococcal infections in 1,486 patients. " 01/01/1986 - "Norfloxacin has a well proven efficacy in UTI but remains to be proven in enteric infections." 06/01/1983 - "Clinical results were excellent in both groups; norfloxacin was effective in infections due to Ps. " 11/01/1986 - "[Epidemiologic and therapeutic study on gonococcal infections--clinical efficacy of norfloxacin]." 01/01/1986 - "Preliminary data from ongoing trials have also shown that norfloxacin is effective in the prophylaxis of traveller's diarrhoea and infections in the granulocytopenic patient. "
2.	Urinary Tract Infections (Urinary Tract Infection) 01/01/1990 - "Norfloxacin was also highly effective in the treatment of multiply resistant, nosocomial urinary tract infections (UTIs), in which Pseudomonas aeruginosa and E. " 04/01/1998 - "Norfloxacin 400 mg twice-a-day has proven to be effective and safe in the treatment of uncomplicated urinary tract infections (UTI). " 06/01/1992 - "-Three days of norfloxacin therapy is more effective than single-dose therapy for women with acute, uncomplicated urinary tract infection. " 01/01/1988 - "The therapeutic efficacy and safety of norfloxacin 400 mg twice daily for 3 or 7 days was compared in a double-blind randomized multiclinic study including 485 female general practice patients with uncomplicated symptomatic lower urinary tract infections. " 04/01/1998 - "In this study, norfloxacin 800 mg once-a-day was as effective and safe as norfloxacin 400 mg twice-a-day in the treatment of uncomplicated urinary tract infections in women."
3.	Bacterial Infections (Bacterial Infection) 06/15/1992 - "Norfloxacin appears to be an effective and relatively safe agent for the treatment of bacterial infections of the eyelids or conjunctiva, or both. " 01/01/1992 - "Norfloxacin appears to be an effective and relatively safe agent for the treatment of bacterial infections of the lids and/or conjunctiva. " 05/01/1992 - "The aim of the study has been to assess if intermittent treatment with norfloxacin could be able to maintain selective intestinal decontamination in cirrhotic patients in order to prevent bacterial infections. " 04/01/2013 - "Norfloxacin is a fluoroquinolone antibiotic used in the treatment of bacterial infections. " 03/16/2011 - "Synthesis and biodistribution of a novel (⁹⁹m)TcN complex of norfloxacin dithiocarbamate as a potential agent for bacterial infection imaging."
4.	Diarrhea 06/26/1987 - "These studies indicate that norfloxacin is safe and effective therapy for bacterial diarrhea." 10/01/1993 - "Norfloxacin proved to be safe and effective in therapy for traveler's diarrhea." 12/01/1998 - "On this trek she had developed diarrhea which had been cured with norfloxacin 400 mg two times per day for 3 days. " 10/01/1993 - "Clinical efficacy of norfloxacin for treatment of traveler's diarrhea in 106 Finnish tourists vacationing in Morocco was evaluated during two different seasons. " 10/01/1993 - "Short-term treatment of traveler's diarrhea with norfloxacin: a double-blind, placebo-controlled study during two seasons."
5.	Peritonitis 03/01/1997 - "Continuous long-term selective intestinal decontamination with norfloxacin is effective in preventing the first spontaneous bacterial peritonitis in cirrhotic patients at high risk. " 06/01/2002 - "Norfloxacin was more effective in the prevention of peritonitis recurrence due to Enterobacteriaceae (0% vs 22%, P = .01). " 01/01/1997 - "The study was performed to compare the spontaneous bacterial peritonitis occurring in patients with and without prophylactic norfloxacin. " 10/01/1990 - "Eighty cirrhotic patients who had recovered from an episode of spontaneous bacterial peritonitis were included in a multicenter, double-blind trial aimed at comparing long-term norfloxacin administration (400 mg/day; 40 patients) vs. placebo (40 patients) in the prevention of spontaneous bacterial peritonitis recurrence. " 07/01/2012 - "Addition of probiotics to norfloxacin does not improve efficacy in the prevention of spontaneous bacterial peritonitis: a double-blind placebo-controlled randomized-controlled trial."

Related Drugs and Biologics

1.	Ciprofloxacin (Cipro)
2.	Trimethoprim-Sulfamethoxazole Combination (Co-Trimoxazole)
3.	Ofloxacin (Levofloxacin)
4.	lomefloxacin (Maxaquin)
5.	Pefloxacin
6.	Ceftriaxone (Ceftriaxon)
7.	Quinolones
8.	Fleroxacin
9.	Aztreonam
10.	Fluoroquinolones

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Catheters
3.	Oral Administration
4.	Antibiotic Prophylaxis
5.	Stents