Human leukocyte antigen haplotypes in the genetic control of immune response to measles-mumps-rubella vaccine.

Abstract

To elucidate the contribution of human leukocyte antigen (HLA) haplotypes and their genotypic combinations to immune status after measles-mumps-rubella (MMR) vaccination, 346 children 12-18 years of age were studied. The class I A*29-Cw*16-B*44 haplotype was associated with lower levels of immunoglobulin G (IgG) antibody to both measles (P=.08) and mumps (P=.03) viral antigens. The A*26-Cw*12-B*38 haplotype was associated with higher cellular immune responses to measles (P=.02) and mumps (P=.01) vaccine viruses. Subjects with the class II DRB1*03-DQB1*02-DPB1*04 haplotype had higher lymphoproliferative responses to measles virus (P=.01) and mumps virus (P=.006). The DRB1*15/16-DQB1*06-DPB1*03 haplotype was associated with high levels of IgG antibody to measles virus (P=.09) but low levels of IgG antibody to rubella virus (P=.02), whereas DRB1*04-DQB1*03-DPB1*03 was associated with high lymphoproliferative responses to both measles (P=.01) and rubella (P=.002) vaccine viruses. A*26-Cw*12-B*38 was associated with both mumps virus-specific humoral (P=.007) and cell-mediated (P=.01) immune responses after 2 doses of MMR vaccine. Haplotype DRB1*04-DQB1*03-DPB1*03 was associated with both lower rubella virus IgG antibody levels (P=.02) and higher rubella virus-specific lymphoproliferation (P=.002). Better characterization of such HLA profiles could inform and improve the design of novel epitope-rich vaccines and help to predict protective immune responses at the individual and population level.

• Authors: Inna G Ovsyannikova, V Shane Pankratz, Robert A Vierkant, Robert M Jacobson, Gregory A Poland
• Journal: The Journal of infectious diseases (J Infect Dis) Vol. 193 Issue 5 Pg. 655-63 (Mar 01 2006) ISSN: 0022-1899 [Print] United States
• PMID: 16453260 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Antibodies, Viral
• HLA Antigens
• Immunoglobulin G
• Measles-Mumps-Rubella Vaccine
• rubella antibodies

Topics

• Adolescent
• Antibodies, Viral (blood)
• Child
• HLA Antigens (genetics, immunology)
• Haplotypes
• Humans
• Immunity, Cellular
• Immunoglobulin G (blood)
• Lymphocyte Activation
• Lymphocytes (immunology)
• Measles virus (immunology)
• Measles-Mumps-Rubella Vaccine (immunology)
• Mumps virus (immunology)
• Statistics as Topic