Lupane-type saponins from leaves of Acanthopanax sessiliflorus and their inhibitory activity on pancreatic lipase.

Abstract

Three known saponins, chiisanoside, 11-deoxyisochiisanoside, and isochiisanoside, and one novel saponin, 3,4-seco-4(23),20(29)-lupadiene-3,28-dioic acid 28-O-alpha-l-rhamnopyranosyl (1-->4)-beta-d-glucopyranosyl (1-->6)-beta-d-glucopyranoside, referred to as sessiloside, were isolated from a hot water extract of Acanthopanax sessiliflorus leaves. All of these saponins were lupane-type triterpene triglycosides, and their concentrations were 4.1, 1.0, 0.5, and 0.4% (w/w) of the total extract, respectively. Sessiloside and chiisanoside inhibited pancreatic lipase activity in vitro, and addition of the saponin-rich fraction to a high-fat diet suppressed the body weight gain of mice. The possibility of application of the lupane-type saponins from A. sessiliflorus leaves to the treatment of obesity is discussed.

• Authors: Kazuma Yoshizumi, Kaoru Hirano, Hidehiro Ando, Yasuaki Hirai, Yoshiteru Ida, Tomoko Tsuji, Tamotsu Tanaka, Kiyoshi Satouchi, Junji Terao
• Journal: Journal of agricultural and food chemistry (J Agric Food Chem) Vol. 54 Issue 2 Pg. 335-41 (Jan 25 2006) ISSN: 0021-8561 [Print] United States
• PMID: 16417288 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Dietary Fats
• Enzyme Inhibitors
• Plant Extracts
• Saponins
• Triterpenes
• Water
• lupane
• Lipase

Topics

• Animals
• Chromatography, High Pressure Liquid
• Dietary Fats (administration & dosage)
• Eleutherococcus (chemistry)
• Enzyme Inhibitors (isolation & purification, pharmacology)
• Female
• Hemolysis
• Hot Temperature
• Lipase (antagonists & inhibitors)
• Mice
• Mice, Inbred ICR
• Pancreas (enzymology)
• Plant Extracts (pharmacology)
• Plant Leaves (chemistry)
• Rats
• Saponins (isolation & purification, pharmacology)
• Triterpenes (isolation & purification, pharmacology)
• Water
• Weight Gain (drug effects)