Defective production of granulocyte-macrophage colony-stimulating factor and interleukin-1 by mononuclear cells from children treated for acute lymphoblastic leukemia.

Abstract

The production of colony-stimulating activity (CSA) by phytohemagglutinin (PHA)-stimulated peripheral blood mononuclear cells (PBMC) from patients receiving maintenance chemotherapy for acute lymphoblastic leukemia (ALL) was examined. Supernatants from only 14 of 22 patient PBMC cultures (64%), but all supernatants from normal PBMC cultures, supported myeloid colony growth. When present, colony-stimulating activity always included granulocyte-macrophage colony-stimulating factor (GM-CSF). In addition, in nine of ten patient studies and in all control studies, stimulated PBMC produced interleukin-1 (IL-1). These results show that the chemotherapy administered to children with ALL can damage the cytokine production mechanisms in PBMC; the diminished ability to produce GM-CSF and IL-1 may contribute to the increased risk of overwhelming infection in these patients.

• Authors: D Ridgway, M S Borzy
• Journal: Leukemia (Leukemia) Vol. 6 Issue 8 Pg. 809-13 (Aug 1992) ISSN: 0887-6924 [Print] England
• PMID: 1640733 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Interleukin-1
• Granulocyte-Macrophage Colony-Stimulating Factor

Topics

• Adolescent
• Antineoplastic Agents (adverse effects)
• Child
• Child, Preschool
• Female
• Granulocyte-Macrophage Colony-Stimulating Factor (biosynthesis)
• Humans
• Interleukin-1 (biosynthesis)
• Leukocytes, Mononuclear (drug effects, metabolism)
• Male
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (drug therapy, immunology)