Abstract |
To investigate the relationship between ionized calcium and disease activity, parameters of bone metabolism and bone mineral density (BMD) at the lumbar spine (BMD-LS) and the femoral neck (BMD-FN) measured by dual X-ray absorptiometry in rheumatoid arthritis (RA). In 146 patients with RA, the following parameters were investigated: serum levels of ionized calcium, total calcium, vitamin D metabolites 25-hydroxyvitamin D3 (25D3) and 1,25-dihydroxyvitamin D3 (1,25D3), intact parathyroid hormone (iPTH), interleukin-6, osteocalcin, erythrocyte sedimentation rate (ESR) and c-reactive protein (CRP); renal excretion of pyridinolin (PYD)- and desoxypyridinolin (DPD)-crosslinks. A total of 30.1% of the patients were hypercalcemic (ionized calcium >1.30 mmol/l). In comparison with normocalcemic patients, those with hypercalcemia had significantly higher ESR (P<0.01) and CRP values (P<0.05) and significantly lower serum levels of both iPTH (P<0.01) and 1,25D3 (P<0.05) and a significantly lower BMD-LS (P<0.05). The results indicate that a substantial part of RA patients is hypercalcemic. Hypercalcemia is associated with high disease activity and may contribute to suppression of PTH secretion and vitamin D hormone synthesis. High levels of ionized calcium may be a reflection of disease-activity-related systemic bone loss, and could be a predictor of BMD at the lumbar spine in RA.
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Authors | Peter Oelzner, Gabriele Lehmann, Thorsten Eidner, Sybille Franke, Andreas Müller, Gunter Wolf, Gert Hein |
Journal | Rheumatology international
(Rheumatol Int)
Vol. 26
Issue 10
Pg. 908-15
(Aug 2006)
ISSN: 0172-8172 [Print] Germany |
PMID | 16404562
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Amino Acids
- Cross-Linking Reagents
- Interleukin-6
- Parathyroid Hormone
- Serum Albumin
- Osteocalcin
- pyridinoline
- deoxypyridinoline
- C-Reactive Protein
- Calcitriol
- Calcifediol
- Calcium
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Topics |
- Absorptiometry, Photon
- Adolescent
- Adult
- Aged
- Amino Acids
(chemistry, urine)
- Arthritis, Rheumatoid
(blood, diagnostic imaging, physiopathology)
- Blood Sedimentation
- Bone Density
- Bone Diseases, Metabolic
(blood)
- C-Reactive Protein
(analysis)
- Calcifediol
(blood)
- Calcitriol
(blood)
- Calcium
(blood)
- Cross-Linking Reagents
(chemistry)
- Female
- Femur Neck
(diagnostic imaging, metabolism)
- Humans
- Hypercalcemia
(blood, physiopathology)
- Interleukin-6
(blood)
- Lumbar Vertebrae
(diagnostic imaging, metabolism)
- Male
- Middle Aged
- Osteocalcin
(blood)
- Parathyroid Hormone
(blood)
- Serum Albumin
(analysis)
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