Abstract |
Thyroid hormone has been reported to affect renal function. To investigate the effects of thyroid hormone on the progression of renal deterioration, thyroid hormone ( dried thyroid) and an antithyroid drug ( thiamazole) were administered to adriamycin (ADR)-induced renal failure rats. The rats were divided into four groups, including 1) ADR-DT, given dried thyroid and thiamazole; 2) ADR-T, given thiamazole; 3) ADR; and 4) control. The survival rate at the end of the study (22 weeks) was 62.5% in ADR-DT group and 100% in ADR-T, ADR, and control groups, respectively. There was a significant difference in the body weight and pulse rate between ADR-DT and ADR-T or ADR groups, except for the pulse rate at week 6 (P<0.05). The creatinine clearance was greater in the ADR-T group than in the ADR or ADR-DT groups at week 22, and was significantly different between the ADR-T and the ADR-DT groups (P<0.05). The fractional kidney weight and tubular changes were significantly greater in the ADR-DT group than in the ADR-T or ADR groups (P<0.05). The interstitial volume was significantly greater in the ADR-DT group than in the ADR-T group (P<0.05). We therefore conclude that a dried thyroid has an aggravative effect in the tubular changes and relative interstitial volume induced by ADR.
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Authors | Toru Sanai, Tadashi Hirano, Masaharu Nagata, Seiya Okuda |
Journal | Renal failure
(Ren Fail)
Vol. 27
Issue 6
Pg. 743-50
( 2005)
ISSN: 0886-022X [Print] England |
PMID | 16350828
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Thyroid Hormones
- Methimazole
- Doxorubicin
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Topics |
- Animals
- Biopsy, Needle
- Blood Pressure Determination
- Body Weight
- Disease Models, Animal
- Doxorubicin
(pharmacology)
- Drug Interactions
- Female
- Heart Rate
- Immunohistochemistry
- Kidney Failure, Chronic
(mortality, pathology, physiopathology)
- Kidney Function Tests
- Male
- Methimazole
(adverse effects, pharmacology)
- Probability
- Random Allocation
- Rats
- Rats, Sprague-Dawley
- Reference Values
- Risk Factors
- Sensitivity and Specificity
- Survival Rate
- Thyroid Hormones
(adverse effects, pharmacology)
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