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Methimazole (Thiamazole)

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A thioureylene antithyroid agent that inhibits the formation of thyroid hormones by interfering with the incorporation of iodine into tyrosyl residues of thyroglobulin. This is done by interfering with the oxidation of iodide ion and iodotyrosyl groups through inhibition of the peroxidase enzyme.

Also Known As:

Thiamazole; Tapazole; 1-Methyl-2-mercaptoimidazole; Eli Lilly Brand of Methimazole; Estedi Brand of Methimazole; Favistan; Henning Berlin Brand of Methimazole; Hexal Brand of Methimazole; Jones Brand of Methimazole; Mercasolyl; Mercazol; Mercazole; Mercazolyl; Merck Brand of Methimazole; Merkazolil; Methizol; Methylmercaptoimidazole; Metisol; Metizol; Nourypharma Brand of Methimazole; Philopharm Brand of Methimazole; Sanofi Synthelabo Brand of Methimazole; Strumazol; Temmler Brand of Methimazole; Thiamazol Henning; Thiamazol Hexal; Thimazol; Thyrozol; Tiamazol; Tirodril; 1 Methyl 2 mercaptoimidazole; Henning, Thiamazol; Hexal, Thiamazol; Methymazol; 2H-Imidazole-2-thione, 1,3-dihydro-1-methyl-

Networked: 1311 relevant articles (100 outcomes, 116 trials/studies)

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Drug Context: Research Results

Experts

1.	Laurberg, Peter: 7 articles (11/2015 - 11/2013)
2.	Noh, Jaeduk Yoshimura: 7 articles (10/2015 - 12/2006)
3.	Ito, Koichi: 6 articles (10/2015 - 12/2006)
4.	Heidari, Reza: 6 articles (04/2015 - 12/2012)
5.	Shibutani, Makoto: 6 articles (03/2015 - 12/2007)
6.	Ahmed, R G: 5 articles (12/2015 - 08/2010)
7.	Chen, Jie: 5 articles (11/2015 - 09/2013)
8.	Wei, Wei: 5 articles (11/2015 - 09/2013)
9.	Song, Binbin: 5 articles (11/2015 - 09/2013)
10.	Min, Hui: 5 articles (11/2015 - 09/2013)

Related Diseases

1.	Hyperthyroidism 09/01/2004 - "The objective of this study was to determine whether transdermal methimazole was as safe and effective as oral methimazole for the control of hyperthyroidism in cats. " 06/01/2014 - "Transdermal methimazole is a safe option for the long-term management of feline hyperthyroidism. " 04/01/2003 - "To determine whether once daily administration of methimazole was as effective and safe as twice daily administration in cats with hyperthyroidism. " 08/01/2001 - "This study evaluated the effect of methimazole pretreatment on the efficacy of 131I therapy in Graves' hyperthyroidism. " 05/01/1993 - "Study 1: GHRH (1 microgram/kg b.w.) was injected i.v. in 38 hyperthyroid patients and in 30 normal subjects; in 11 of the patients the GHRH test was repeated following methimazole-induced remission of hyperthyroidism. "
2.	Graves Disease (Basedow Disease) 01/01/2015 - "Remission of Graves' disease is not related to early restoration of euthyroidism with high-dose methimazole therapy." 07/01/1999 - "Seventeen pediatric patients (mean age at diagnosis 10 yr and 9 mo +/- 2 yr and 9 mo) with Graves' disease treated with 0.3-0.7 mg/kg/day methimazole and followed for at least three years, during which drug suspension was attempted on attainment of good clinical and metabolic compensation, were retrospectively studied to look for factors predictive of lasting remission present at onset. " 01/01/2014 - "She was diagnosed with Graves' disease and started on methimazole, which relieved her symptoms for a few months. " 01/01/2013 - "In many countries, methimazole (MMI) therapy is the first-line treatment in children with Graves' disease (GD). " 05/01/2001 - "We examined the following four groups: patients with untreated thyrotoxic Graves' disease (untreated group), patients with Graves' disease treated with methimazole (treated group), patients in remission (remission group), and healthy volunteers (control group). "
3.	Psoriasis (Pustulosis Palmaris et Plantaris) 10/01/2004 - "We have previously reported that an antithyroid thiourethylene, thiamazole, can bring about significant clinical improvement in patients with psoriasis vulgaris. " 10/01/2004 - "This preliminary study suggests that thiamazole administration is an effective and relatively safe treatment for patients with psoriasis vulgaris." 01/01/1993 - "Methimazole, an antithyroid drug, was orally administered, in an open trial, in a dose of 20 mg every 12 h for 8 weeks to 8 volunteers with long-standing psoriasis. " 01/01/1993 - "Methimazole (2-mercapto 1-methyl imidazole) in psoriasis--results of an open trial." 01/01/1993 - "Methimazole may be an effective therapeutic agent in the management of psoriasis; it most probably exerts its therapeutic effect by acting on the immune system."
4.	Hypothyroidism 05/01/2013 - "Treadmill exercise ameliorates symptoms of methimazole-induced hypothyroidism through enhancing neurogenesis and suppressing apoptosis in the hippocampus of rat pups." 06/01/2015 - "Thus, our study indicated that dietary methimazole-induced hypothyroidism could disturb the normal processes of lipid metabolism at the enzymatic and molecular levels in yellow catfish, and the reduced hepatic lipid content by hypothyroidism was attributable to the down-regulation of lipogenesis and up-regulation of lipolysis. " 06/01/2015 - "The present study was conducted to investigate the effects and mechanisms of hypothyroidism, induced by administration of 0.2% methimazole through the food, on lipid metabolism in the liver of juvenile yellow catfish Pelteobagrus fulvidraco. " 01/01/2015 - "In this study, we evaluated the effect of methimazole-induced hypothyroidism on the vascularization and immune cells infiltration into islets. " 06/01/2014 - "Therefore, our aim is to study the effects of developmental hypothyroxinemia, caused by mild ID, and developmental hypothyroidism, caused by severe ID or methimazole (MMZ), on the proliferation of cerebellar granule neuron precursors (CGNPs), an excellent experimental model of cerebellar development and function. "
5.	Agranulocytosis (Granulocytopenia) 11/01/1993 - "The present study was undertaken to determine the efficacy of rhG-CSF administration in patients with methimazole-induced (MMI) agranulocytosis. " 01/01/2013 - "[Acute agranulocytosis from thiamazole: points for improvement in daily practice]." 06/01/2006 - "After initiation of treatment with 30 mg of thiamazole daily, the patient's thyroid function improved but 4 weeks later, thiamazole induced agranulocytosis occurred and the drug was discontinued. " 05/01/1991 - "Methimazole and agranulocytosis--clinical study." 01/01/2015 - "The occurrence of agranulocytosis in continuous ATD treatment patients is well known; however, a case of ATD agranulocytosis occurring following the discontinuation of methimazole (MMI) treatment is not a usual situation. "

Related Drugs and Biologics

1.	Propylthiouracil
2.	Thyroxine (Levothyroxine)
3.	Propranolol (Inderal)
4.	Thyrotropin (Thyroid-Stimulating Hormone)
5.	Thyroid Hormones
6.	Hormones
7.	Antithyroid Agents (Antithyroid Drugs)
8.	Antibodies
9.	Immunoglobulin E (IgE)
10.	Interleukin-13

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Thyroidectomy
3.	Nephrectomy
4.	Retreatment
5.	Transplantation (Transplant Recipients)