Abstract | OBJECTIVE: METHODS: Six adult patients with burns greater than 40% of their body surface underwent metabolic evaluation utilizing isotopic dilution of phenylalanine, femoral arterial and venous blood sampling, and sequential biopsies of leg muscle. Following baseline measurements, insulin was infused into the femoral artery at 0.45 mIU/min 100 mL leg volume. Patients were then given metformin (850 mg every 8 hours) for seven days with repeat metabolic evaluation before and during intra-arterial infusion of insulin. RESULTS: Intra-arterial administration of insulin significantly increased insulin concentrations within the femoral vein, creating hyperinsulinemia localized to the extremity. Metformin had no significant effect on either peripheral glucose clearance or the rate of glucose oxidation. Furthermore, the availability of ATP and energy charge within muscle was not overtly affected by either insulin or metformin. Metformin did significantly increase the fractional synthetic rate of muscle protein which increased even further with insulin administration. Both metformin and insulin separately increased the rate of muscle protein synthesis as calculated using three compartment modeling. CONCLUSION:
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Authors | Dennis C Gore, David N Herndon, Robert R Wolfe |
Journal | The Journal of trauma
(J Trauma)
Vol. 59
Issue 2
Pg. 316-22; discussion 322-3
(Aug 2005)
ISSN: 0022-5282 [Print] United States |
PMID | 16294070
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- Hypoglycemic Agents
- Insulin
- Muscle Proteins
- Metformin
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Topics |
- Adult
- Blood Glucose
(drug effects, metabolism)
- Burns
(metabolism)
- Humans
- Hypoglycemic Agents
(administration & dosage, pharmacology)
- Infusions, Intra-Arterial
- Insulin
(administration & dosage, pharmacology)
- Metformin
(administration & dosage, pharmacology)
- Middle Aged
- Muscle Proteins
(drug effects, metabolism)
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