Radiation induced meningioma with a short latent period following high dose cranial irradiation - case report and literature review.

Abstract

Radiation induced meningiomas (RIM) are rare late complications in patients who have received high dose irradiation for brain tumors. The mean latency period for induction of RIM in most of the series is 18.7+/-10.2 years. There are only 9 reported cases of RIM following high dose cranial irradiation with unusually short latency periods of less than 5 years. Herein, we report a child diagnosed with RIM with an unusually short latency period of 14 months. An 11-year old male child underwent gross total resection of medulloblastoma. Following surgery he received high dose craniospinal irradiation. Postoperative computed tomography scan (CT scan) after 1 month did not show features of any residual tumor, recurrence or tumor at a new site. The child was asymptomatic for 14 months and then presented with complaints of headache and vomiting. CT scan head showed multiple solid homogenously enhancing lesions in bilateral basifrontal and right basitemporal region. Histopathology of the lesions turned out to be atypical meningioma.

• Authors: Ajay Choudhary, Satyajit Pradhan, Mohammad Fakhrul Huda, Sureswar Mohanty, Mohan Kumar
• Journal: Journal of neuro-oncology (J Neurooncol) Vol. 77 Issue 1 Pg. 73-7 (Mar 2006) ISSN: 0167-594X [Print] United States
• PMID: 16292489 (Publication Type: Case Reports, Journal Article, Review)

Topics

• Age Factors
• Brain Neoplasms (diagnosis, radiotherapy, surgery)
• Child
• Cranial Irradiation (adverse effects)
• Humans
• Male
• Medulloblastoma (radiotherapy)
• Meningioma (diagnosis, etiology, surgery)
• Neoplasms, Radiation-Induced (diagnosis, etiology, surgery)
• Radiotherapy Dosage
• Time Factors
• Tomography, X-Ray Computed
• Treatment Outcome