CYP17 gene polymorphism in relation to breast cancer risk: a case-control study.

Abstract

INTRODUCTION:

The c.1-34T>C 5' promoter region polymorphism in cytochrome P450c17 (CYP17), a key enzyme in the biosynthesis of estrogen, has been associated with breast cancer risk, but most previous studies have been relatively small.

METHODS:

We genotyped 1,544 incident cases of primary breast cancer and 1,502 population controls, all postmenopausal Swedish women, for the CYP17 c.1-34T>C polymorphism and calculated odds ratios (ORs) and 95% confidence intervals (CIs) from logistic regression models.

RESULTS:

No overall association was found between CYP17 c.1-34T>C and breast cancer risk, OR 1.0 (95% CI 0.8-1.3) for the A2/A2 (CC) carriers compared to the A1/A1 (TT) carriers, regardless of histopathology. We detected an interaction between CYP17 c.1-34T>C and age at menarche (P = 0.026) but regarded that as a chance finding as no dose-response pattern was evident. Other breast cancer risk factors, including menopausal hormone use and diabetes mellitus, did not modify the overall results.

CONCLUSION:

It is unlikely that CYP17 c.1-34T>C has a role in breast cancer etiology, overall or in combination with established non-genetic breast cancer risk factors.

• Authors: Kristjana Einarsdóttir, Tove Rylander-Rudqvist, Keith Humphreys, Susanne Ahlberg, Gudrun Jonasdottir, Elisabete Weiderpass, Kee Seng Chia, Magnus Ingelman-Sundberg, Ingemar Persson, Jianjun Liu, Per Hall, Sara Wedrén
• Journal: Breast cancer research : BCR (Breast Cancer Res) Vol. 7 Issue 6 Pg. R890-6 ( 2005) ISSN: 1465-542X [Electronic] England
• PMID: 16280037 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Steroid 17-alpha-Hydroxylase

Topics

• Aged
• Breast Neoplasms (genetics)
• Case-Control Studies
• Female
• Genetic Predisposition to Disease
• Humans
• Middle Aged
• Odds Ratio
• Polymorphism, Genetic
• Postmenopause
• Steroid 17-alpha-Hydroxylase (genetics)