Serum osteoprotegerin levels are associated with inflammation and pulse wave velocity.

Abstract

OBJECTIVE:

We examined the association between serum osteoprotegerin (OPG) levels, systemic inflammation and arterial stiffness in normal and diabetic patients.

PATIENTS AND MEASUREMENTS:

The study subjects comprised 49 newly diagnosed diabetic patients and 72 age- and sex-matched normal glucose controls. Anthropometric parameters, blood pressure, fasting blood glucose (FBG), lipid profiles, serum OPG, high-sensitive C-reactive protein (hsCRP), interleukin-6 (IL-6) and brachial-ankle pulse wave velocity (baPWV) were measured.

RESULTS:

Serum OPG levels (6.1 +/- 1.4 vs. 5.4 +/- 1.3 pmol/l, P = 0.011) and baPWV (1562 +/- 354 vs. 1399 +/- 257 cm/s, P = 0.004) were significantly higher in the diabetic group than in the normal glucose group. Serum OPG levels in normal and diabetic patients correlated significantly with systolic blood pressure (r = 0.20, P = 0.035), FBG (r = 0.30, P = 0.002), right baPWV (r = 0.22, P = 0.021), left baPWV (r = 0.26, P = 0.006), homeostasis model assessment insulin resistance (HOMA-IR) (r = 0.19, P = 0.045), IL-6 (r = 0.32, P = 0.001) and hsCRP (r = 0.21, P = 0.027) after adjusting for age and sex. Multiple regression analysis showed that serum OPG level was significantly associated with age, FBG, IL-6, systolic blood pressure, triglyceride and hsCRP (R(2) = 0.299).

CONCLUSIONS:

In summary, serum OPG and baPWV levels are elevated in diabetic patients and serum OPG levels are significantly associated with inflammation and arterial stiffness.

• Authors: S M Kim, J Lee, O H Ryu, K W Lee, H Y Kim, J A Seo, S G Kim, N H Kim, S H Baik, D S Choi, K M Choi
• Journal: Clinical endocrinology (Clin Endocrinol (Oxf)) Vol. 63 Issue 5 Pg. 594-8 (Nov 2005) ISSN: 0300-0664 [Print] England
• PMID: 16268814 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Blood Glucose
• Glycoproteins
• Interleukin-6
• Lipids
• Osteoprotegerin
• Receptors, Cytoplasmic and Nuclear
• Receptors, Tumor Necrosis Factor
• TNFRSF11B protein, human
• Triglycerides
• C-Reactive Protein

Topics

• Biomarkers (blood)
• Blood Glucose (analysis)
• Brachial Artery (physiopathology)
• C-Reactive Protein (analysis)
• Case-Control Studies
• Diabetes Mellitus (blood, physiopathology)
• Female
• Glycoproteins (blood)
• Humans
• Hypertension (blood, physiopathology)
• Inflammation (blood, physiopathology)
• Insulin Resistance
• Interleukin-6 (blood)
• Lipids (blood)
• Male
• Middle Aged
• Osteoprotegerin
• Pulsatile Flow
• Receptors, Cytoplasmic and Nuclear (blood)
• Receptors, Tumor Necrosis Factor (blood)
• Regression Analysis
• Signal Processing, Computer-Assisted
• Systole
• Triglycerides (blood)