Fasting apoprotein B-48 level and coronary artery disease in a population without frank fasting hypertriglyceridemia.

Abstract

The aim of this study was to test the hypothesis that fasting apoprotein B-48 level might be a surrogate marker of postprandial lipemia in evaluating the risk of coronary artery disease (CAD) in a population without frank abnormality in fasting lipid profile. One hundred twenty-three patients tested by coronary angiography were selected on the criteria of absence of treatment with hypolipidemic drugs, obvious hypertriglyceridemia (>2.85 mmol/L), or other conditions that may interfere with lipoprotein metabolism except diabetes. CAD was defined by more than 50% narrowing of vessel lumen, and its severity is determined by the number of arteries involved. Fasting apoprotein B-48 was measured by a competitive enzyme-linked immunosorbent assay method. There was no difference in fasting apoprotein B-48 levels between the groups with and without CAD (0.123+/-0.096 vs 0.136+/-0.125 microg/mL, respectively), whatever the sex or whether with or without diabetes. The apoprotein B-48 level was not related to the presence or the severity of CAD. There was also no correlation between fasting apoprotein B-48 levels and age, sex, body mass index, and usual fasting lipid parameters in both patients with and without angiographically proven CAD. Finally, among the features of metabolic syndrome, apoprotein B-48 was correlated with fasting triglyceride levels (r=0.357, P<.01) only. In conclusion, the present study shows that in the absence of any major fasting abnormality in plasma lipid parameters, fasting apoprotein B-48 level, which has been associated with postprandial hyperlipidemia, does not predict the risk of CAD.

• Authors: René Valero, Anne-Marie Lorec, Franck Paganelli, Sophie Beliard, Catherine Atlan, Denis Lairon, Bernard Vialettes, Henri Portugal
• Journal: Metabolism: clinical and experimental (Metabolism) Vol. 54 Issue 11 Pg. 1442-7 (Nov 2005) ISSN: 0026-0495 [Print] United States
• PMID: 16253631 (Publication Type: Journal Article)

Chemical References

• Apolipoprotein B-48
• Apolipoproteins B
• Biomarkers
• Triglycerides
• Cholesterol

Topics

• Aged
• Apolipoprotein B-48
• Apolipoproteins B (blood)
• Biomarkers (blood)
• Cholesterol (blood)
• Coronary Artery Disease (epidemiology, metabolism)
• Fasting
• Female
• Humans
• Hypertriglyceridemia
• Male
• Middle Aged
• Predictive Value of Tests
• Risk Factors
• Triglycerides (blood)