Abstract | PURPOSE: The aim of this study was to explore the effect of dose-dense sequential chemotherapy with or without paclitaxel primarily on disease-free survival (DFS) and secondarily on overall survival (OS) in patients with high-risk operable breast cancer. PATIENTS AND METHODS: RESULTS: A total of 595 patients were eligible. Median follow-up was 61.7 months for group A and 62 months for group B. The 3-year DFS was 80% in group A and 77% in group B. Survival rates were 93% and 90%, respectively. The effect of treatment on the hazard of death was different according to hormonal receptor status. More specifically, in patients with negative receptor status the hazard of death was significantly higher for group B (hazard ratio 2.42). Both regimens were well tolerated and severe acute side-effects were infrequent. No cases of severe cardiotoxicity or acute leukemia were recorded. CONCLUSIONS: The present study failed to demonstrate a significant difference in DFS or OS between the two treatment groups. However, our study has shown clearly that high-dose paclitaxel can be safely incorporated to dose-dense sequential chemotherapy.
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Authors | G Fountzilas, D Skarlos, U Dafni, H Gogas, E Briasoulis, D Pectasides, C Papadimitriou, C Markopoulos, A Polychronis, H P Kalofonos, V Siafaka, P Kosmidis, E Timotheadou, D Tsavdaridis, D Bafaloukos, P Papakostas, E Razis, P Makrantonakis, G Aravantinos, C Christodoulou, A-M Dimopoulos |
Journal | Annals of oncology : official journal of the European Society for Medical Oncology
(Ann Oncol)
Vol. 16
Issue 11
Pg. 1762-71
(Nov 2005)
ISSN: 0923-7534 [Print] England |
PMID | 16148021
(Publication Type: Clinical Trial, Phase III, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Epirubicin
- Cyclophosphamide
- Paclitaxel
- Fluorouracil
- Methotrexate
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Topics |
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage, therapeutic use)
- Breast Neoplasms
(drug therapy, surgery)
- Cyclophosphamide
(administration & dosage)
- Disease-Free Survival
- Dose-Response Relationship, Drug
- Epirubicin
(administration & dosage)
- Female
- Fluorouracil
(administration & dosage)
- Humans
- Methotrexate
(administration & dosage)
- Middle Aged
- Paclitaxel
(administration & dosage)
- Risk Factors
- Survival Rate
- Treatment Outcome
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