Abstract | PURPOSE: MATERIALS AND METHODS: Male rats with BOO were used. Six to 8 days after obstruction voiding behavior was observed in a metabolic cage. The animals were then treated orally with 1 drug, and voiding frequency and urine volume at each void were measured for 3 hours. Subsequently the volume of urine retained in the bladder (residual urine) was measured. In another experiment bladder weight in rats with BOO was measured after early repeat doses of TAK-802. RESULTS: BOO increased voiding frequency and decreased average voided volume. TAK-802 and distigmine increased average voided volume, while not causing any change in voiding frequency. On the other hand, bethanechol increased voiding frequency without affecting average voided volume. While all 3 drugs significantly decreased residual urine volume, TAK-802 was most efficacious. In addition, bladder weight in the control BOO group was greater (approximately 2.2-fold) than that in the sham operated group and early repeat administration of TAK-802 prevented the bladder mass increase. CONCLUSIONS: AChE inhibitors decreased residual urine volume by restoring voiding function in rats with BOO, although only the effect of TAK-802 was dose dependent. Bethanechol also decreased residual urine volume in a dose dependent manner but by increasing voiding frequency. The prevention of a bladder mass increase by TAK-802 treatment may be attributable to its effect on restoring voiding.
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Authors | Tadatoshi Hashimoto, Hiroshi Nagabukuro, Takayuki Doi |
Journal | The Journal of urology
(J Urol)
Vol. 174
Issue 3
Pg. 1137-41
(Sep 2005)
ISSN: 0022-5347 [Print] United States |
PMID | 16094081
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Cholinesterase Inhibitors
- Muscarinic Agonists
- Pyridinium Compounds
- Pyrroles
- Quinolones
- Bethanechol
- 8-(3-(1-((3-fluorophenyl)methyl)-4-piperidinyl)-1-oxopropyl)-1,2,5,6-tetrahydro-4H-pyrrolo(3,2,1-ij)quinolin-4-one
- distigmine
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Topics |
- Administration, Oral
- Animals
- Bethanechol
(pharmacology)
- Cholinesterase Inhibitors
(pharmacology)
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Male
- Mice
- Muscarinic Agonists
(pharmacology)
- Organ Size
(drug effects)
- Pyridinium Compounds
(pharmacology)
- Pyrroles
(pharmacology)
- Quinolones
(pharmacology)
- Rats
- Rats, Wistar
- Urinary Bladder
(drug effects, pathology, physiopathology)
- Urinary Bladder Neck Obstruction
(physiopathology)
- Urination
(drug effects, radiation effects)
- Urodynamics
(drug effects, physiology)
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