Urinary Bladder Neck Obstruction (Bladder Neck Obstruction)

Blocked urine flow through the bladder neck, the narrow internal urethral opening at the base of the URINARY BLADDER. Narrowing or strictures of the URETHRA can be congenital or acquired. It is often observed in males with enlarged PROSTATE glands.

Also Known As:

Networked: 862 relevant articles (70 outcomes, 126 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Prostatic Hyperplasia (Benign Prostatic Hyperplasia)
2.	Prostatic Neoplasms (Prostate Cancer)
3.	Overactive Urinary Bladder (Overactive Bladder)
4.	Fibrosis (Cirrhosis)
5.	Hyperplasia

Experts

1.	Levin, Robert M: 15 articles (11/2014 - 03/2002)
2.	Chacko, Samuel: 13 articles (03/2013 - 06/2002)
3.	Wein, Alan J: 11 articles (10/2015 - 06/2002)
4.	Zderic, Stephen A: 11 articles (03/2013 - 06/2002)
5.	Kim, Joon Chul: 10 articles (03/2015 - 10/2004)
6.	Lin, Wei-Yu: 9 articles (11/2014 - 12/2007)
7.	Chang, Shaohua: 9 articles (05/2013 - 06/2002)
8.	Mannikarottu, Anita: 9 articles (01/2009 - 01/2006)
9.	Kuo, Hann-Chorng: 8 articles (05/2015 - 05/2004)
10.	Matsumoto, Seiji: 8 articles (12/2014 - 06/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Urinary Bladder Neck Obstruction:

1.	tamsulosin (Flomax)FDA LinkGeneric 03/01/2006 - "These results suggest that tamsulosin will be useful in the treatment of voiding dysfunction associated with bladder outlet obstruction in women, with little hypotensive effect." 09/18/2006 - "These results partly support the fact that tamsulosin has improved storage symptoms as well as voiding symptoms in patients with lower urinary tract symptoms associated with bladder outlet obstruction by blocking alpha(1)-adrenoceptors." 01/01/2004 - "In both groups, tamsulosin improved the IPSS and QOL index and the bladder outlet obstruction index (BOOI) was lowered without reducing the bladder contractility index (BCI). " 06/01/2002 - "The aim of this study was to assess whether, in patients with bladder outlet obstruction (BOO), tamsulosin treatment produced any significant change in UEBW. " 01/01/2015 - "To estimate efficacy and treatment satisfaction with tamsulosin 0.2 mg in patients with symptomatic bladder outlet obstruction secondary to benign prostatic enlargement and lower urinary tract symptoms in relation to personal satisfaction. "
2.	Terazosin (Hytrin)FDA LinkGeneric 04/01/1996 - "Terazosin treatment results in symptomatic relief and improved urinary flow in patients with and without bladder outlet obstruction, and in significant improvement in patients with urodynamically proved obstruction." 01/01/2000 - "Terazosin in a dose of 10 mg/day was well tolerated and effective in reducing bladder outlet obstruction in many spinal cord-injured patients, as reflected by a decrease in maximum detrusor pressure and MUPG in 49% of the patients. " 06/01/2002 - "Terazosin treatment, even 2 mg. daily, urodynamically relieved bladder outlet obstruction in Japanese patients with symptomatic BPH without any changes in detrusor contractility." 10/01/2006 - "These results suggest that terazosin may be an effective treatment option in women with voiding dysfunction due to functional bladder outlet obstruction." 10/01/2006 - "In a prospective pilot study 15 women with functional bladder outlet obstruction were treated with terazosin. "
3.	CollagenIBA 01/01/2012 - "Human MSCs overexpressing HGF inhibited collagen deposition and improved cystometric parameters in bladder outlet obstruction of rats. " 02/01/2012 - "As the transforming growth factor-β1 (TGF-β1) that induces the synthesis of collagen in the penile tissues is critical for the development of ED, the first aim of this study was to investigate the expression of TGF-β1 in the penis from male rabbits with chronic partial bladder outlet obstruction (PBOO). " 01/01/2012 - "The present study is to investigate if human mesenchymal stem cells (MSCs) are capable of inhibiting collagen deposition and improve cystometric parameters in bladder outlet obstruction in rats. " 01/01/2000 - "This study was undertaken to investigate the effects of partial bladder outlet obstruction and its relief on types I and III collagen, and the relationship between detrusor contractility and collagen types. " 01/01/1997 - "This study suggests that bladder outlet obstruction in the fetus is not associated with excess collagen deposition but rather with an increased amount of bladder with normal cellular content and a concomitant increase in smooth muscle development."
4.	NeodymiumIBA 04/01/1999 - "Neodymium:YAG laser ablation of prostate represents an efficacious surgical intervention for symptomatic bladder outlet obstruction due to BPH with minimal associated morbidity." 06/01/1992 - "Seventeen patients with bladder neck obstruction due to benign prostatic hypertrophy have been treated with the Neodymium: YAG laser. " 01/01/2003 - "Side firing Neodymium:Yag laser prostatectomy offers a safe and effective treatment for bladder outlet obstruction due to benign hyperplasia with minimal associated morbidity." 09/01/1995 - "This prospective study was undertaken to evaluate the safety and efficacy of visual laser ablation of the prostate with the Prolase 2 sidefiring neodymium: YAG laser fiber in patients with symptomatic bladder outlet obstruction due to benign prostatic hyperplasia (BPH). " 03/01/1997 - "Sixty-seven patients with symptomatic bladder outlet obstruction due to benign prostatic hyperplasia were entered into a prospective trial where VLAP was done with neodymium:YAG laser, while the bladder neck incision was done with KTP laser. "
5.	alfuzosin (UroXatral)FDA Link 01/01/1998 - "The study comprised two substudies: in the first, 205 patients with lower urinary tract symptoms (LUTS) suggestive of bladder outlet obstruction (BOO), a Madsen-Iversen score > 6 and a maximum flow rate of < 10 mL/s were randomized to receive either placebo or alfuzosin in a double-blind study of 16 weeks. " 06/01/2012 - "Alfuzosin may relieve storage symptoms suggestive of OAB in patients with or without bladder outlet obstruction (BOO). " 02/01/2009 - "Our objective was to assess the effect of the selective alpha(1)-blocker alfuzosin on urodynamic parameters and quality of life in female patients with primary bladder neck obstruction (PBNO). " 02/01/2009 - "Effect of alfuzosin on female primary bladder neck obstruction." 03/01/2005 - "To assess the effect on sexual function of alfuzosin 10 mg once daily, a uroselective alpha(1)-blocker, in men with lower urinary tract symptoms (LUTS) suggestive of bladder outlet obstruction. "
6.	KMD 3213FDA Link 12/01/2014 - "The pressure flow studies demonstrated that silodosin had significantly enlarged the bladder capacity when the first non-voiding contraction was seen at 3 and 12 months (3M: 127.1 ± 74.8 vs. 118.2 ± 83.9 mL, p = 0.001; 12M: 123.7 ± 79.3 vs. 100.3 ± 73.4 mL, p = 0.01); however, there were no improvements in the bladder outlet obstruction index (BOOI) or urinary flow. " 10/05/2015 - "Effect of silodosin, a selective α1A-adrenoceptor antagonist, on voiding behavior and bladder blood flow in a rat model of bladder outlet obstruction." 09/01/2012 - "Silodosin is an effective and well-tolerated treatment for the relief of both voiding and storage symptoms in patients with lower urinary tract symptoms suggestive of bladder outlet obstruction thought to be associated with benign prostatic hyperplasia. " 03/01/2011 - "Silodosin is an effective and well-tolerated treatment for the relief of both voiding and storage symptoms in patients with lower urinary tract symptoms suggestive of bladder outlet obstruction thought to be associated with benign prostatic hyperplasia. " 07/01/2002 - "It is concluded that KMD-3213 may produce fairly selective and sustained occupancy of alpha1-adrenoceptors in the prostate, a target organ for treatment of bladder outlet obstruction in patients with benign prostatic hyperplasia."
7.	Doxazosin (Cardura)FDA LinkGeneric 09/01/2012 - "Effect of doxazosin on expression of eNOS in rat kidney in the presence of partial bladder outlet obstruction." 10/01/2005 - "Men 50 years or older with OAB symptoms and urodynamically proven bladder outlet obstruction (Abrams-Griffith score greater than 20) were randomized (1:2) into 2 groups, namely group 1-doxazosin controlled release gastrointestinal therapeutic system formulation (4 mg once daily) only and group 2-propiverine hydrochloride (20 mg once daily) plus doxazosin controlled release gastrointestinal therapeutic system formulation for an 8-week treatment regimen. " 06/01/1996 - "To assess the urodynamic changes in men with lower urinary tract symptoms (LUTS) suggestive of bladder outlet obstruction treated with doxazosin and to correlate these changes with voiding symptoms. " 06/01/1995 - "A 3-month double-blind study of doxazosin as treatment for benign prostate bladder outlet obstruction." 07/01/1994 - "A three month double-blind study of doxazosin as treatment for benign prostatic bladder outlet obstruction."
8.	Finasteride (Propecia)FDA LinkGeneric 07/01/2000 - "While alpha-blockers have a rapid onset of action, likely to produce a therapeutic result within weeks, regardless of whether prostatic enlargement or bladder outlet obstruction is present, finasteride appears to be effective for more long-term therapy for up to 4 years, but only in alleviating symptoms when they are associated with a significantly large prostate. " 01/01/2001 - "Patients with symptomatic bladder outlet obstruction and moderately enlarged prostates can receive durable relief from finasteride. " 01/01/2001 - "Patients with symptomatic bladder outlet obstruction and moderately enlarged prostates who are placed initially on combination therapy using finasteride and an alpha-blocker are likely to tolerate discontinuation of the alpha-blocker after 9 months of combination therapy." 01/01/1996 - "Finasteride therapy reduces the volume of the hyperplastic prostate gland by more than 20%, improves the urinary flow rate and the symptoms associated with bladder outlet obstruction. " 10/01/1995 - "Finasteride decreases bladder outlet obstruction moderately and only occasionally relieves it completely. "
9.	potassium titanylphosphateIBA 01/01/2009 - "To study the results and complications of the potassium-titanyl-phosphate (KTP, green) laser during transurethral incision of the bladder neck in the treatment of female voiding dysfunction due to bladder neck obstruction. " 10/01/2004 - "A prospective clinical trial was performed in 139 men clinically diagnosed with symptomatic bladder outlet obstruction secondary to BPH who were enrolled and treated with a high power, 80 W, quasicontinuous wave potassium-titanyl-phosphate laser at 6 American medical centers across the country. " 12/01/2012 - "There is little data evaluating the changes of severity of bladder outlet obstruction after 80 W-potassium-titanyl-phosphate (KTP) photoselective laser vaporization prostatectomy (PVP) by pressure-flow study. " 09/01/2007 - "To assess the efficacy of photoselective vaporization of the prostate (PVP) in men with prostates of >100 mL and causing bladder outlet obstruction (BOO), using the high-power 80 W potassium-titanyl-phosphate laser (GreenLight PV, Laserscope, San Jose, CA, USA), which offers rapid tissue ablation with minimal bleeding. " 05/01/2001 - "To study the feasibility of vaporization prostatectomy by potassium-titanyl-phosphate (KTP/532) laser in men with bladder outlet obstruction due to benign prostatic hyperplasia (BPH) and to evaluate their clinical and voiding outcome 2 weeks and 6 months after operation. "
10.	Cholinergic Antagonists (Anticholinergics)IBA 01/01/2007 - "We searched Medline, Embase and Cochrane databases (1966-2006), and hand-searched relevant reference lists and conference proceedings, for studies on the use of anticholinergics in men with BPH or bladder outlet obstruction. " 05/01/2005 - "The study included 53 patients with DO from neurogenic (NDO, 10), previous bladder outlet obstruction (BOO, 20) or idiopathic cause (IDO, 23) and who were refractory to anticholinergic agents. " 04/01/2013 - "Anticholinergics are a valuable option for management of iOAB, and have a growing role in management of lower urinary tract symptoms in men without bladder outlet obstruction." 03/01/2008 - "Anticholinergic agents are effective in relieving overactive bladder symptoms in patients without bladder outlet obstruction. " 01/01/2004 - "It is a common perception that using an anticholinergic drug in men with bladder outlet obstruction runs the risk of inducing acute urinary retention, because of the inhibitory effect of anticholinergics on bladder contraction in the presence of outlet obstruction. "

Therapies and Procedures

1.	Transurethral Resection of Prostate (TURP) 05/01/1998 - "High energy transurethral microwave thermotherapy relieved bladder outlet obstruction in 60% of the patients and had a good effect on symptoms. " 10/01/1996 - "In conclusion, TUVP with the VaporTrode yields a significant improvement in AUA symptom score, peak uroflow rate, PVR, and detrusor pressure at maximum flow, denoting relief of bladder outlet obstruction. " 06/01/1998 - "This study provides objective evidence that TUVP is effective in providing prompt relief of bladder outlet obstruction with durable improvement in symptoms and flow rate with no acute morbidity. " 06/01/2006 - "Both HoLEP and TURP were equally effective in relieving bladder outlet obstruction. " 05/01/1995 - "In small prostates TURP and TUIP were generally equally effective in relieving bladder outlet obstruction secondary to BPH. "
2.	Prostatectomy (Retropubic Prostatectomy) 07/01/2011 - "The study also included the initial biopsies of such patients, and an additional 10 simple prostatectomies from patients with bladder outlet obstruction. " 12/01/2005 - "To assess the long-term outcomes of untreated bladder outlet obstruction (BOO), assuming that, if there is little or no deterioration, a conservative approach to management is justified, as there is little information on the natural history of untreated BOO and lower urinary tract symptoms (LUTS) in men, and studies to date suggest that neither BOO nor LUTS inevitably progress to a stage at which prostatectomy is required. " 01/01/1997 - "This study was designed to determine and compare the uroflow parameters of normal men and patients after prostatectomy in order to investigate the flow rate expression in men without bladder outlet obstruction. " 09/01/2015 - "Some patients with the indication of radical prostatectomy (RP) have often undergone previous surgical treatment for bladder outlet obstruction (BOO). " 01/01/2015 - "Prostatic periurethral tissue samples were obtained from ten patients (age range 65 to 79 years, mean 66) with clinical symptoms of bladder outlet obstruction who had undergone open prostatectomy. "
3.	Solid-State Lasers 07/01/2008 - "Should holmium laser enucleation be the new gold standard for bladder outlet obstruction caused by BPH?" 01/01/2012 - "Intermediate-term efficacy of Tm:YAG laser prostate vaporesection for bladder outlet obstruction: initial experience from a UK teaching hospital." 01/01/2014 - "A retrospective review using a prospectively maintained database was performed of patients treated for bladder outlet obstruction secondary to a prostate smaller than 40 ml. Patients who were treated with GreenLight™ photoselective vaporization of the prostate or holmium laser transurethral incision of the prostate were included in the study. " 07/01/2015 - "We determine the impact of prostate size on the long-term outcome of holmium laser transurethral incision of the prostate (Ho-TUIP) for bladder outlet obstruction (BOO) secondary to benign prostate enlargement (BPE). " 02/01/2014 - "Holmium laser enucleation of the prostate for relief of bladder outlet obstruction enabled discharge of urine. "
4.	Lasers (Laser) 11/01/1999 - "Hybrid laser treatment compared with transurethral resection of the prostate for symptomatic bladder outlet obstruction caused by a large benign prostate: a prospective, randomized trial with a 6-month follow-up." 07/01/1995 - "A urodynamic study was done to judge the capability of laser treatment to relieve bladder outlet obstruction. " 11/01/2015 - "The GreenLight XPS™ 180-watt laser is an effective treatment option for bladder outlet obstruction with a low perioperative complications rate, and it shows results comparable with transurethral resection of the prostate. " 11/01/2015 - "The objective was to assess and publish our first experiences with the GreenLight XPS™ 180-watt laser in men suffering from bladder outlet obstruction. " 05/01/2015 - "Forty patients with lower urinary tract symptoms suggesting bladder outlet obstruction, with a prostate heavier than 70 g on transrectal ultrasound, were selected to undergo laparoscopic adenomectomy or Eraser laser enucleation of the prostate. "
5.	Stents 10/01/1996 - "Prostatic stents can be effective in relieving bladder outlet obstruction caused by BPH. " 05/01/2003 - "Thermo-expandable intraprostatic stents in bladder outlet obstruction: an 8-year study." 02/01/2003 - "This study was designed to evaluate the feasibility, efficacy and complications of treatment of bladder neck obstruction by Memotherm stent. " 08/01/2002 - "Thermo-expandable intraprostatic stents in bladder outlet obstruction: an 8-year study." 09/01/2007 - "We report our experience with the Abbey-Moor Spanner temporary prostatic stent in patients with acute and chronic symptoms of bladder-outlet obstruction secondary to benign or malignant disease who were unfit for surgery because of age or cardiorespiratory disease. "