Assessment of PINK1 (PARK6) polymorphisms in Finnish PD.

Abstract

Recent data has demonstrated that mutations in PINK1, encoding PTEN-induced kinase 1, are a cause of early onset recessive parkinsonism (PARK6 locus). Common variability in genes implicated in hereditary forms of parkinsonism may be a predisposing factor in sporadic Parkinson's disease (PD). We analyzed whether six different genetic variants within and surrounding PINK1 contribute to the risk of sporadic PD in a Finnish case-control series. Our results indicate that this gene does not play a major role in the genetic predisposition to PD in this population.

• Authors: Jordi Clarimón, Johanna Eerola, Olli Hellström, Terhi Peuralinna, Pentti J Tienari, Andrew B Singleton
• Journal: Neurobiology of aging (Neurobiol Aging) Vol. 27 Issue 6 Pg. 906-7 (Jun 2006) ISSN: 0197-4580 [Print] United States
• PMID: 16046032 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Protein Kinases
• PTEN-induced putative kinase

Topics

• Adult
• Aged
• Aged, 80 and over
• DNA Mutational Analysis (methods)
• Female
• Finland (epidemiology)
• Humans
• Male
• Middle Aged
• Parkinson Disease (epidemiology, genetics)
• Polymorphism, Genetic (genetics)
• Protein Kinases (genetics)