Talnetant GlaxoSmithKline.

Abstract

Talnetant (SB-223412) is a selective, orally active NK3 antagonist based on 4-quinolinecarboxamide, and is under development by GlaxoSmithKline (formerly SmithKline Beecham) for the potential treatment of several disorders, including urinary incontinence, irritable bowel syndrome and schizophrenia. By November 2004, the compound had completed phase II trials.

• Authors: Stefano Evangelista
• Journal: Current opinion in investigational drugs (London, England : 2000) (Curr Opin Investig Drugs) Vol. 6 Issue 7 Pg. 717-21 (Jul 2005) ISSN: 1472-4472 [Print] England
• PMID: 16044668 (Publication Type: Journal Article, Review)

Chemical References

• Quinolines
• Receptors, Tachykinin
• SB 223412

Topics

• Animals
• Clinical Trials, Phase II as Topic
• Humans
• Irritable Bowel Syndrome (drug therapy)
• Molecular Structure
• Quinolines (chemistry, pharmacology, therapeutic use)
• Receptors, Tachykinin (antagonists & inhibitors, physiology)
• Schizophrenia (drug therapy)
• Treatment Outcome
• Urinary Incontinence (drug therapy)