Expression of c-erbB-2 and glutathione S-transferase-pi in hepatocellular carcinoma and its adjacent tissue.

Abstract

AIM:

To investigate the possible role of c-erbB-2 and glutathione S-transferase (GST-Pi) in primary hepatocellular carcinogenesis and the relationship between liver hype-rplastic nodule (LHN), liver cirrhosis (LC), and hepatocellular carcinoma (HCC).

METHODS:

The expression of c-erbB-2 and GST-Pi was detected immunohistochemically in 41 tissue specimens of HCC and 77 specimens of its adjacent tissue.

RESULTS:

The positive expression of c-erbB-2 in LHN (28.6%) was significantly higher than that in LC (0%) (P = 0.032<0.05), but no significant difference was seen between HCC and LHN or LC (P>0.05, chi2= 0.002, 3.447). The positive expression of GST-Pi in HCC (89.6%) or LHN (71.1%) was significantly higher than that in LC (22.9%, P<0.001, chi2= 49.91, 16.96). There was a significant difference between HCC and LHN (P<0.05, chi2= 6.353).

CONCLUSION:

The c-erbB-2 expression is an early event in the pathogenesis of HCC. GST-Pi may be a marker enzyme for immunohistochemical detection of human HCC and its preneoplastic lesions. LHN seems to be a preneoplastic lesion related to hepatocarcinogenesis.

• Authors: Zhao-Shan Niu, Mei Wang
• Journal: World journal of gastroenterology (World J Gastroenterol) Vol. 11 Issue 28 Pg. 4404-8 (Jul 28 2005) ISSN: 1007-9327 [Print] United States
• PMID: 16038042 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• Isoenzymes
• GSTP1 protein, human
• Glutathione S-Transferase pi
• Glutathione Transferase
• Receptor, ErbB-2

Topics

• Biomarkers, Tumor (metabolism)
• Carcinoma, Hepatocellular (metabolism, pathology)
• Female
• Glutathione S-Transferase pi
• Glutathione Transferase (metabolism)
• Humans
• Isoenzymes (metabolism)
• Liver (metabolism, pathology)
• Liver Neoplasms (metabolism, pathology)
• Male
• Middle Aged
• Receptor, ErbB-2 (metabolism)