Abstract | BACKGROUND:
Bupropion has been available in the United States since 1989. Initially a thrice-daily immediate-release formulation, a twice-daily sustained-release formulation followed in 1996, and, in August 2003, a once-daily extended-release formulation was introduced. On the 15th anniversary of its introduction, we undertook a review of the background/history, mechanism of action, formulations, and clinical profile of bupropion. DATA SOURCES: Major efficacy trials and other reports were obtained and reviewed from MEDLINE searches, review of abstracts from professional meetings, and the bupropion SR manufacturer's databases. Searches of English-language articles were conducted from June 2003 through August 2004. No time limit was specified in the searches, which were conducted using the search terms bupropion, bupropion SR, and bupropion XL. DATA SYNTHESIS: CONCLUSION:
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Authors | Maurizio Fava, A John Rush, Michael E Thase, Anita Clayton, Stephen M Stahl, James F Pradko, J Andrew Johnston |
Journal | Primary care companion to the Journal of clinical psychiatry
(Prim Care Companion J Clin Psychiatry)
Vol. 7
Issue 3
Pg. 106-13
( 2005)
ISSN: 1523-5998 [Print] United States |
PMID | 16027765
(Publication Type: Journal Article)
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