Abstract | BACKGROUND: OBJECTIVE: We tested the hypothesis that increasing the protein content while maintaining the carbohydrate content of the diet lowers body weight by decreasing appetite and spontaneous caloric intake. DESIGN: Appetite, caloric intake, body weight, and fat mass were measured in 19 subjects placed sequentially on the following diets: a weight-maintaining diet (15% protein, 35% fat, and 50% carbohydrate) for 2 wk, an isocaloric diet (30% protein, 20% fat, and 50% carbohydrate) for 2 wk, and an ad libitum diet (30% protein, 20% fat, and 50% carbohydrate) for 12 wk. Blood was sampled frequently at the end of each diet phase to measure the area under the plasma concentration versus time curve (AUC) for insulin, leptin, and ghrelin. RESULTS: Satiety was markedly increased with the isocaloric high-protein diet despite an unchanged leptin AUC. Mean (+/-SE) spontaneous energy intake decreased by 441 +/- 63 kcal/d, body weight decreased by 4.9 +/- 0.5 kg, and fat mass decreased by 3.7 +/- 0.4 kg with the ad libitum, high-protein diet, despite a significantly decreased leptin AUC and increased ghrelin AUC. CONCLUSIONS:
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Authors | David S Weigle, Patricia A Breen, Colleen C Matthys, Holly S Callahan, Kaatje E Meeuws, Verna R Burden, Jonathan Q Purnell |
Journal | The American journal of clinical nutrition
(Am J Clin Nutr)
Vol. 82
Issue 1
Pg. 41-8
(Jul 2005)
ISSN: 0002-9165 [Print] United States |
PMID | 16002798
(Publication Type: Clinical Trial, Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Dietary Proteins
- Ghrelin
- Insulin
- Leptin
- Peptide Hormones
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Topics |
- Adult
- Appetite
(drug effects)
- Area Under Curve
- Body Composition
- Body Weight
(drug effects)
- Circadian Rhythm
- Dietary Proteins
(administration & dosage, pharmacology)
- Energy Intake
- Ghrelin
- Humans
- Insulin
(blood)
- Leptin
(blood)
- Middle Aged
- Peptide Hormones
(blood)
- Satiation
(drug effects)
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