[Population pharmacokinetics of carbamazepine in adults with epilepsy].

Abstract

The aim of the present study was to determinate the factors affecting carbamazepine (CBZ) clearance (CL) in adults with epilepsy using a mixed-effect model and sparse data collected during routine clinical care. The patient population comprised 104 adults receiving CBZ. A total of 161 CBZ steady state serum concentration samples were analyzed. Population CL was calculated by using NONMEM with a one compartment model with first-order absorption and elimination. The following covariates were tested for their influence on clearance (CL): total body weight, age, dose/day, sex, surface area (SA) and comedication with primidone (PRIM), ualproic acid or phenytoin (DFH). The final regression model for carbamazepine clearance found best to describe the data was: CL = (0.614 SA + 0.0016 dose/day)(1 + 0.278 DFH)(1 + 0.326 PRIM).

• Authors: Silvia Romano-Moreno, Eréndida Lizbeth Medina-Rojas, Ana Luisa Salas-Ortiz, Juan Manuel Vargas-Morales, José Trinidad Pérez-Urizar, Idelfonso Rodríguez-Leyva
• Journal: Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion (Rev Invest Clin) 2005 Jan-Feb Vol. 57 Issue 1 Pg. 38-48 ISSN: 0034-8376 [Print] Mexico
• Vernacular Title: Farmacocinética poblacional de carbamacepina en pacientes epilépticos adultos.
• PMID: 15981957 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Carbamazepine

Topics

• Adolescent
• Adult
• Carbamazepine (pharmacokinetics)
• Epilepsy (metabolism)
• Female
• Humans
• Male
• Middle Aged
• Retrospective Studies