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Primidone (Sertan)

An antiepileptic agent related to the barbiturates; it is partly metabolized to PHENOBARBITAL in the body and owes some of its actions to this metabolite. Adverse effects are reported to be more frequent than with PHENOBARBITAL. (From Martindale, The Extra Pharmacopoeia, 30th ed, p309)

Also Known As:

Sertan; Mysoline; Apo-Primidone; Liskantin; Mylepsinum; Resimatil; Apotex Brand of Primidone; Astra Brand of Primidone; AstraZeneca Brand of Primidone; Desitin Brand of Primidone; Draxis Brand of Primidone; Holsten Brand of Primidone; Misodine; Mizodin; Primidon Holsten; Sanofi-Synthelabo Brand of Primidone; Xcel Brand of Primidone; Zeneca Brand of Primidone; Desoxyphenobarbital; Primaclone; 4,6(1H,5H)-Pyrimidinedione, 5-ethyldihydro-5-phenyl-

Networked: 326 relevant articles (34 outcomes, 26 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 319
    - Pyrimidinones: 14
      - Barbiturates: 929
        Phenobarbital: 13192
        Primidone: 326
        4-hydroxyprimidone

Experts

1.	Deuschl, Günther: 2 articles (01/2014 - 02/2011)
2.	Zesiewicz, Theresa A: 2 articles (02/2013 - 09/2004)
3.	Gironell, Alexandre: 2 articles (07/2009 - 11/2007)
4.	Bazil, C W: 2 articles (11/2008 - 05/2007)
5.	Buchsbaum, R: 2 articles (11/2008 - 05/2007)
6.	Arif, H: 2 articles (11/2008 - 05/2007)
7.	Hirsch, L J: 2 articles (11/2008 - 05/2007)
8.	Resor, S R: 2 articles (11/2008 - 05/2007)
9.	Raethjen, J: 2 articles (08/2008 - 01/2007)
10.	Alonso-Navarro, Hortensia: 2 articles (07/2008 - 01/2006)

Related Diseases

1.	Seizures (Seizure) 09/01/1988 - "Efficacy of primidone for seizure control in neonates and young infants." 05/01/2005 - "Depression was common and associated with inadequate seizure control and use of primidone." 05/01/2005 - "After logistic regression, inadequate seizure control (OR 3.08, 95% CI 1.40-6.77, P=0.005) and use of primidone (OR 4.08, 95% CI 2.09-7.98; P<0.001) remained significantly associated. " 11/22/2003 - "If primidone treatment is discontinued too quickly, withdrawal seizures may appear, some of which may be severe. " 10/01/2000 - "The primidone dose was then increased by 125 to 250 mg every 3 weeks until adverse events or a seizure-free state was reached. "
2.	Tremor (Tremors) 02/01/2013 - "The decision to discontinue primidone after surgery resulted in a non-significant long-term improvement in tremor motor score (23 points versus 15 points, p = 0.19), and did not significantly influence the physical and mental composite quality of life scores (p = 0.81, 0.23, respectively). " 09/01/2012 - "The aim of our study was to determine the tolerability and efficacy of primidone in reducing severe cerebellar tremor in patients with MS. Ten patients with severe cerebellar tremor were enrolled in this study. " 01/01/1991 - "The tremor had not been helped by beta-blockers or primidone. " 09/01/2012 - "Our study showed that primidone is tolerable in MS patients and effectively reduces severe cerebellar tremor in such patients." 07/01/2013 - "The tDLB tremors were reduced by acute and chronic dopaminergic treatments (p < 0.01) but not by alcohol or primidone. "
3.	Essential Tremor (Essential Tremors) 01/17/1981 - "Primidone is highly effective in benign familial tremor. " 09/01/1985 - "Uncontrolled clinical studies have suggested that primidone may be effective in reducing essential tremor thus providing a valuable alternative to beta-adrenoreceptor antagonists which are currently the drugs of first choice. " 02/01/1990 - "The long-term efficacy of primidone (375-750 mg/day) in essential tremor was evaluated prospectively in 11 patients who had shown a favorable response to 4-week treatment with the drug under placebo-controlled conditions. " 01/01/1986 - "Primidone is an effective agent for the treatment of essential tremor." 07/01/2012 - "Primidone is a minor first-generation antiepileptic drug, little currently prescribed for this indication, but except marketing authorization, remains a first-line treatment of essential tremor. "
4.	Epilepsy (Aura) 06/01/1956 - "[Critical study of the value of primidone in the treatment of epilepsy]." 05/01/2005 - "Primidone is associated with interictal depression in patients with epilepsy." 09/15/1982 - "Treatment of canine epilepsy with primidone." 11/01/1979 - "On account of the similarities in metabolism and pharmacokinetics of primidone in dog and man, the former species seems to be a suitable model in epilepsy research. " 05/01/1979 - "The results support our findings of negligible or absent PRM concentrations in the brains of patients on primidone therapy who were undergoing surgery for intractable epilepsy. "
5.	Vomiting 05/01/1987 - "However, primidone was significantly even more effective in the beginning after only 2 doses, when at the same time 10 of 13 patients showed a maximum of acute toxic side-effects producing nausea, vomiting, giddiness and/or sedation. " 07/18/1985 - "Differences in failure rates of the drugs were explained primarily by the fact that primidone caused more intolerable acute toxic effects, such as nausea, vomiting, dizziness, and sedation. " 05/01/1992 - "Case No. 1 presented with ataxia, lethargy, vomiting, and leaning and falling to the right, and had a transient remission following radiation and corticosteroid therapy; case No. 2 had a history of seizures that were unresponsive to primidone, left-sided postural reaction deficits, ataxia, and circling to the right; case No. 3 had only intermittent episodes of vomiting Computed tomography of case Nos. "

Related Drugs and Biologics

1.	Phenobarbital (Luminal)
2.	Propranolol (Inderal)
3.	Carbamazepine (Tegretol)
4.	Clonazepam (Rivotril)
5.	Pentylenetetrazole (Metrazol)
6.	Phenytoin (Dilantin)
7.	Valproic Acid (Valproate, Semisodium)
8.	gabapentin (Neurontin)
9.	Phenylethylmalonamide
10.	Primidone (Sertan)

Related Therapies and Procedures

1.	Deep Brain Stimulation
2.	Drug Therapy (Chemotherapy)
3.	Oral Administration
4.	Compressed Air
5.	Premedication