Abstract | BACKGROUND/AIMS: METHODS: RESULTS: At baseline, 14 (15%) of the 95 patients were obese and 26 (27%) had type 2 diabetes mellitus. Fifty-seven patients were infected with HCV genotype 1 and 38 with genotype 2. Steatosis and periportal fibrosis was present in 44 (46%) and 69 (73%), respectively. In multivariate analysis, male gender, insulin resistance, high HCV load and genotype 2 were significantly associated with a lower serum adiponectin level. In contrast, intrahepatic gene expression of adiponectin receptors was higher in genotype 2 compared with genotype 1. Serum adiponectin level did not correlate with other clinical or histologic parameters. After treatment, change of steatosis also did not correlate with the change of adiponectin level (P=0.61). CONCLUSIONS:
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Authors | Chun-Jen Liu, Pei-Jer Chen, Yung-Ming Jeng, Wen-Ling Huang, Wei-Shiung Yang, Ming-Yang Lai, Jia-Horng Kao, Ding-Shinn Chen |
Journal | Journal of hepatology
(J Hepatol)
Vol. 43
Issue 2
Pg. 235-42
(Aug 2005)
ISSN: 0168-8278 [Print] Netherlands |
PMID | 15964656
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- ADIPOR1 protein, human
- ADIPOR2 protein, human
- Adiponectin
- Biomarkers
- Intercellular Signaling Peptides and Proteins
- RNA, Messenger
- RNA, Viral
- Receptors, Adiponectin
- Receptors, Cell Surface
- Complement C1q
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Topics |
- Adiponectin
- Biomarkers
(blood)
- Complement C1q
(metabolism)
- Disease Progression
- Fatty Liver
(etiology, metabolism, pathology)
- Female
- Follow-Up Studies
- Genotype
- Hepacivirus
(genetics, isolation & purification)
- Hepatitis C, Chronic
(metabolism, pathology, virology)
- Humans
- Intercellular Signaling Peptides and Proteins
(blood)
- Liver
(metabolism, pathology, virology)
- Liver Cirrhosis
(etiology, metabolism, pathology)
- Male
- Middle Aged
- Polymerase Chain Reaction
- RNA, Messenger
(biosynthesis, genetics)
- RNA, Viral
(genetics)
- Receptors, Adiponectin
- Receptors, Cell Surface
(genetics, metabolism)
- Retrospective Studies
- Viral Load
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