Abstract | AIM:
Adenosine has many actions potentially useful as adjunct to a cardioplegia. Defibrotide was recently shown to have protective effects during cardiac arrest. The aim of this study was to compare these 2 substances to delineate their profile of action in the setting of cardioplegic arrest. METHODS: RESULTS: The time to attain heart arrest was 20% shorter in group A, but this difference did not reach statistical significance (A: 13.6+/-1.5; D: 16.8+/-2.7; C: 17.3+/-2.2 s). The heart rate during reperfusion in group A was almost identical to baseline, while in both group C and D it was significantly lower ( A: 101%, D: 93.4%, C: 82.4%, p<0.01).A and D decreased significantly the release of creatine phospokinase compared to group C (p=0.006). Lactate dehydrogenase release was lower in both treatment groups, although statistical significance was not reached. Peak positive dP/dT decreased more in controls during reperfusion (A: -23+/-6%, D: -17+/-5%, C: -31+/-5%, p=ns). Negative dP/dT was significantly worse in controls compared to both treatments ( A: -19+/-6%, D: -12+/-5%, C: -34+/-7%, p=0.035). CONCLUSIONS: Both adenosine and defibrotide have protective effects in an isolated model of cardioplegic arrest. Adenosine is significantly more active on heart rate while defibrotide is more active on contractily. Further studies are justified in order to test the combination of these 2 drugs.
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Authors | V Mantovani, G Mariscalco, P Borsani, S Tenconi, V D Bruno, C Leva, S Ferrarese, A Sala |
Journal | The Journal of cardiovascular surgery
(J Cardiovasc Surg (Torino))
Vol. 46
Issue 3
Pg. 291-6
(Jun 2005)
ISSN: 0021-9509 [Print] Italy |
PMID | 15956928
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cardioplegic Solutions
- Drug Combinations
- Fibrinolytic Agents
- Polydeoxyribonucleotides
- Vasodilator Agents
- defibrotide
- Adenosine
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Topics |
- Adenosine
(pharmacology)
- Animals
- Cardioplegic Solutions
(pharmacology, standards)
- Coronary Circulation
(drug effects)
- Disease Models, Animal
- Drug Combinations
- Fibrinolytic Agents
(pharmacology)
- Heart Arrest, Induced
(methods)
- Heart Rate
(drug effects)
- In Vitro Techniques
- Male
- Myocardial Ischemia
(physiopathology, prevention & control)
- Polydeoxyribonucleotides
(pharmacology)
- Rats
- Rats, Wistar
- Recovery of Function
(drug effects, physiology)
- Vasodilator Agents
(pharmacology)
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