Abstract | BACKGROUND: AIM: METHODS: We enrolled 287 patients, 173 with duodenal ulcer and 114 with gastric ulcer and 100 patients with H. pylori-positive gastritis as control subjects. Patients with peptic ulcer were classified according to whether or not they received famotidine-maintenance therapy (20 mg/day) after primary treatment. At the time of endoscopy, biopsy specimens were obtained from the antrum and the corpus. The degrees of neutrophil and lymphocyte infiltration, atrophy and intestinal metaplasia were scored according to the updated Sydney System. RESULTS: The degrees of neutrophil infiltration and atrophy in the corpus were significantly less in patients with gastric ulcer or duodenal ulcer than in patients with H. pylori-positive gastritis (P < 0.01). Differences in the degrees of neutrophil infiltration and atrophy in the corpus between the non-maintenance group and the maintenance group were not significant. CONCLUSION:
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Authors | T Kamada, J Hata, H Kusunoki, K Sugiu, M Ito, S Tanaka, Y Kawamura, K Chayama, K Haruma |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 21 Suppl 2
Pg. 99-104
(Jun 2005)
ISSN: 0269-2813 [Print] England |
PMID | 15943855
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Antacids
- Anti-Ulcer Agents
- Histamine H2 Antagonists
- Famotidine
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Topics |
- Adolescent
- Adult
- Aged
- Antacids
(administration & dosage)
- Anti-Ulcer Agents
(administration & dosage)
- Famotidine
(administration & dosage)
- Female
- Gastric Acid
(metabolism)
- Gastritis
(complications, drug therapy, pathology)
- Helicobacter Infections
- Helicobacter pylori
- Histamine H2 Antagonists
(administration & dosage)
- Humans
- Lymphocytes
- Male
- Middle Aged
- Neutrophils
- Peptic Ulcer
(complications, drug therapy)
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