Natural and hybrid ("chimeric") stable regulatory glyproline peptides.

Abstract

The present concept of relative instability of regulatory peptides (RPs) in organisms must be amended. The recently characterized family of glyprolines and some other prolyl-glycyl-proline (PGP)-containing oligopeptides show the stability quite comparable with those of major pharmacological preparations. The ability of glyprolines to pass gastro-enteric tract barriers opens ways to per-oral administration of this new group of drugs such as semax, selank and their fragments. The most interesting approach is the creation of hybrid ("chimeric") peptide drugs combining the unmodified representatives of various natural RPs that distinctly manifest their inherent physiological activities and cooperate with each other in stabilization of whole peptide in vivo. As the result, the activity of such peptides as semax and selank may have value in a vide variety of pathological processes.

• Authors: I P Ashmarin, G E Samonina, L A Lyapina, A A Kamenskii, N G Levitskaya, I A Grivennikov, O V Dolotov, L A Andreeva, N F Myasoedov
• Journal: Pathophysiology : the official journal of the International Society for Pathophysiology (Pathophysiology) Vol. 11 Issue 4 Pg. 179-185 (May 2005) ISSN: 0928-4680 [Print] Switzerland
• PMID: 15837162 (Publication Type: Journal Article)