Pro-Gly-Pro- ACTH (4-7)

08/01/1999 - "[Study of the efficacy of semax in global cerebral ischemia in vivo]."
10/01/2011 - "In this context, the effects of Semax and its C-end tripeptide PGP on the functional morphology of nervous tissue cells were studied in the normal rat brain and in a model of incomplete global rat brain ischemia. "
07/01/2011 - "Semax increases erythrocyte deformability in the shearing blood stream in intact rats and rats with cerebral ischemia."
06/01/2017 - "To reveal biological processes and signaling pathways, which are affected by Semax and PGP, we performed the transcriptome analysis of cerebral cortex of rats with focal cerebral ischemia treated by these peptides. "
01/01/2009 - "[Effect of semax and mexidol on brain ischemia models in rats]."

01/01/2018 - "[The efficacy of semax in the tretament of patients at different stages of ischemic stroke]."
01/01/1997 - "[Effectiveness of semax in acute period of hemispheric ischemic stroke (a clinical and electrophysiological study)]."
01/01/2016 - "High similarity between the effects of Ttr and coupled molecular systems with the Semax effects in ischemic stroke allowed us to suggest that the neuroprotection mechanisms of Semax (and, possibly, of other neuroprotection mechanisms of Semax) could be mediated by Ttr. "
01/01/2008 - "Semax is known to stimulate learning and memory and can be successfully used for treatment of ischemic stroke. "
01/01/1999 - "A clinical trial was performed of immunobiochemical mechanisms of neuroprotective properties of Semax in acute period of ischemic stroke. "

01/01/2023 - "Furthermore, we showed that both Semax and ACTH(6-9)PGP can partially prevent changes in the immune- and neurosignaling-related gene expression profiles disturbed by the action of ischemia at 4.5 h after tMCAO. "
06/01/2017 - "We suppose that neuroprotective mechanism of Semax is realized via the neuroimmune crosstalk, and the new properties of PGP were found under ischemia. "
01/01/2016 - "The full-genome analysis of the transcriptome implemented in our recent work dem- onstrated that under conditions of focal ischemia of rat brain the Semax modified the profile of the transcription activity of many genes. "
03/24/2014 - "In conditions of rat brain focal ischemia, Semax influenced the expression of genes that promote the formation and functioning of the vascular system.The"
05/01/2013 - "Our results showed that semax prevents activating effect ofhypoxia on the Vegfa gene expression in early stages of global ischemia. "

01/01/2005 - "Semax treatment resulted in significant clinical improvement, stabilization of the disease progress and reduced a risk of stroke and transitory ischemic attacks in the disease course. "
05/01/2021 - "We conclude that the observed protective effect of Semax in the model of stroke may be due to its anti-inflammatory effects. "
01/01/2010 - "Consisting of a fragment of ACTH(4-7) and C-terminal PGP tripeptide, the polypeptide Semax is successfully used for acute stroke therapy. "
06/08/2021 - "Here, we aimed to evaluate the effect of Semax in this model via the brain expression profiling of key proteins involved in inflammation and cell death processes (MMP-9, c-Fos, and JNK), as well as neuroprotection and recovery (CREB) in stroke. "
02/01/2013 - "The synthetic peptide Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is used successfully in acute stroke therapy. "

12/01/2006 - "Neuroprotective and antiamnesic effects of Semax during experimental ischemic infarction of the cerebral cortex."
12/01/2006 - "Intranasal administration of Semax for 6 days decreased the volume of cortical infarction and improved retention and performance of conditioned passive avoidance response."