[Transcriptional regulation of the sarcoplasmic reticulum Ca2+ -ATPase gene].

Abstract

Sarcoplasmic reticulum Ca(2+)-ATPase is a key protein which takes Ca(2+) up into sarcoplasmic reticulum, thereby controls relaxation of cardiac muscle. The expression level of Ca(2+)-ATPase mRNA is regulated transcriptionally under various pathophysiological conditions. The E-Box, CArG Box, and MCAT element are essential for the muscle-specific transcription of the gene. Egr-1 sites in the proximal regulatory region of the gene are responsible for the decreased expression of Ca(2+)-ATPase mRNA in heart failure. Additionally, both proximal and distal regulatory elements are important for the transcriptional suppression of the gene.

• Authors: M Arai
• Journal: Clinical calcium (Clin Calcium) Vol. 11 Issue 4 Pg. 436-44 (Apr 2001) ISSN: 0917-5857 [Print] Japan
• PMID: 15775538 (Publication Type: English Abstract, Journal Article)