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Schistosomal hepatic fibrosis and the interferon gamma receptor: a linkage analysis using single-nucleotide polymorphic markers.

Abstract
A minority of individuals infected with the parasite Schistosoma mansoni develops hepatic fibrosis. HLA studies in Egypt and a candidate gene search in a Sudanese population indicate that the host's genetics contribute to disease susceptibility. In an Egyptian community, 32.7% of individuals 11 years and older had significant fibrosis by WHO ultrasound criteria. Linkage to 10 candidate genes was tested using 89 affected sibling pairs from 40 pedigrees in this community. The candidates included genes that initiate fibrosis, participate in collagen synthesis, or control collagen degradation. Two to four single-nucleotide polymorphisms (SNPs) were genotyped per locus, and 188 individuals were genotyped at 48 markers. Model-free modified Haseman-Elston analysis identified linkage to a SNP in the interferon gamma receptor locus (P=0.000001). There was also weak evidence for linkage to the interleukin 13-4 region and tissue growth factor beta 1.
AuthorsRonald E Blanton, Ekram Abdel Salam, Amgad Ehsan, Charles H King, Katrina Ab Goddard
JournalEuropean journal of human genetics : EJHG (Eur J Hum Genet) Vol. 13 Issue 5 Pg. 660-8 (May 2005) ISSN: 1018-4813 [Print] England
PMID15756299 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Genetic Markers
  • Interleukin-13
  • Receptors, Interferon
  • interferon gamma receptor
Topics
  • Adolescent
  • Adult
  • Egypt
  • Female
  • Genetic Linkage
  • Genetic Markers
  • Genetic Predisposition to Disease
  • Humans
  • Interleukin-13 (genetics)
  • Liver Cirrhosis (diagnostic imaging, genetics, parasitology)
  • Liver Diseases, Parasitic (complications, diagnostic imaging, genetics, parasitology)
  • Male
  • Pedigree
  • Polymorphism, Single Nucleotide
  • Receptors, Interferon (genetics)
  • Schistosomiasis mansoni (complications, diagnostic imaging, genetics, parasitology)
  • Ultrasonography

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