[Cardiovascular dysfunction following severe scorpion envenomation. Mechanisms and physiopathology].

Abstract

The seriousness of scorpion envenomation results essentially from left cardiac function with pulmonary oedema and/or a state of shock. Adrenergic myocarditis, toxic myocarditis and myocardial ischemia are the 3 mechanisms that explain the cardiac dysfunction. Myocardial ischemia is not only due to the release of catecolamines but also the effect of the cytokines and/or neuropeptide Y on the coronary vessels. The cardiac damage can be due or enhanced by the depressive effect of the cytokines on the myocardial cells. The frequently observed hyperglycaemia only enhances the state of the already damaged myocardium.

• Authors: Mabrouk Bahloul, Hatem Kallel, Noureddine Rekik, Chokri Ben Hamida, Hédi Chelly, Mounir Bouaziz
• Journal: Presse medicale (Paris, France : 1983) (Presse Med) Vol. 34 Issue 2 Pt 1 Pg. 115-20 (Jan 29 2005) ISSN: 0755-4982 [Print] France
• Vernacular Title: Atteinte cardiovasculaire lors d'envenimation scorpionique grave. Mécanismes et physiopathologie.
• PMID: 15687982 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Catecholamines
• Cytokines
• Endothelin-1
• Neuropeptide Y
• Scorpion Venoms
• beta-Thromboglobulin

Topics

• Acidosis (etiology, physiopathology)
• Animals
• Blood Platelets (physiology)
• Catecholamines (physiology)
• Cytokines (physiology)
• Endothelin-1 (physiology)
• Humans
• Hyperglycemia (etiology, physiopathology)
• Myocardial Ischemia (diagnosis, etiology, physiopathology)
• Myocarditis (diagnosis, etiology, physiopathology)
• Myocardium (cytology, immunology)
• Neuropeptide Y (physiology)
• Pulmonary Edema (etiology, physiopathology)
• Scorpion Stings (complications)
• Scorpion Venoms (adverse effects)
• Scorpions
• Shock, Cardiogenic (etiology, physiopathology)
• Stress, Physiological (etiology, physiopathology)
• beta-Thromboglobulin (physiology)