Abstract | BACKGROUND:
Angiotensin II infusion into rats causes iron deposition in the kidney, which may augment the pro-proteinuric effects of this octapeptide. We have investigated whether administration of iron mimics the renal damage induced by angiotensin II. METHODS: Rats were treated with iron dextran at a total dose of 960 mg/kg either with or without angiotensin II treatment at a dose of 0.7 mg/kg/day for 7 days. Protein expression of ferritin and heme oxygenase-1, an oxidative stress-sensitive gene, was determined by Western blot analysis and immunohistochemistry. RESULTS: CONCLUSION:
Iron dextran did not enhance or cause the renal dysfunction in the angiotensin II-treated or untreated rats, respectively. The distribution of deposited iron and presumably the type of iron compound administered may be important determinants of the development of renal injury.
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Authors | Nobukazu Ishizaka, Kan Saito, Eisei Noiri, Masataka Sata, Ichiro Mori, Minoru Ohno, Ryozo Nagai |
Journal | Nephron. Physiology
(Nephron Physiol)
Vol. 98
Issue 4
Pg. p107-13
( 2004)
ISSN: 1660-2137 [Electronic] Switzerland |
PMID | 15627796
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2004 S. Karger AG, Basel. |
Chemical References |
- Angiotensin II
- Iron-Dextran Complex
- Ferritins
- Iron
- Heme Oxygenase (Decyclizing)
- Hmox1 protein, rat
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Topics |
- Angiotensin II
- Animals
- Blood Pressure
(drug effects)
- Body Weight
(drug effects)
- Ferritins
(metabolism)
- Heme Oxygenase (Decyclizing)
(metabolism)
- Iron
(analysis, blood)
- Iron Overload
(chemically induced, complications, metabolism)
- Iron-Dextran Complex
- Kidney
(chemistry, metabolism, physiopathology)
- Kidney Diseases
(chemically induced, metabolism, physiopathology)
- Male
- Proteinuria
(chemically induced)
- Rats
- Rats, Sprague-Dawley
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